Mast cell degranulation alters lymphatic contractile activity through action of histamine

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Kelly J Plaku, Pierre-Yves von der Weid

Abstract

Mast cells reside in most tissues and in close association with blood vessels and nerves, areas where lymphatic vessels are also present. Mast cells and lymphatic vessels are two important players in the development of the inflammatory process. This study was designed to examine the effects of mast cell degranulation on the contractile activity of mesenteric lymphatic vessels. Lymphatic vessel contractile activity was assessed in vitro by video microscopy of the mesentery of cow's milk-sensitized guinea pigs upon application of beta-lactoglobulin and compared to the response measured in sham animals. Application of 5-10 microM beta-lactoglobulin increased lymphatic vessel constriction frequency and decreased constriction amplitude (n = 12). This effect was not seen in sham-treated animals (n = 16) and was not due to an increased number of mast cells in the mesentery of the milk-sensitized animals, as revealed by histological examination. Two known mast cell-derived mediators, histamine and thromboxane A2, via stable mimetic U46619 also altered lymphatic pumping in a similar manner, but only pretreatment with the histamine H1 receptor antagonist pyrilamine (1 microM) could reduce the beta-lactoglobulin-induced response. The thro...Continue Reading

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Citations

Jul 18, 2012·Bulletin of Experimental Biology and Medicine·G I Lobov, M N Pan'kova
May 19, 2007·Lymphatic Research and Biology·Patrick M LynchGeert W Schmid-Schönbein
Jul 29, 2010·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S G PetunovE R Nikitina
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Oct 27, 2010·Annals of the New York Academy of Sciences·Pierre-Yves Von Der Weid, Sonia Rehal
Apr 8, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kristine H KurtzJerome W Breslin
May 4, 2017·International Journal of Molecular Sciences·Sarit PalAnatoliy A Gashev
Nov 27, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Olga Y GashevaAnatoliy A Gashev
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