PMID: 9550219Apr 29, 1998Paper

Mast cell distribution in nodules of Onchocerca volvulus from untreated patients with generalized onchocerciasis

Parasitology
G WildenburgD W Büttner

Abstract

Onchocercomata with a defined worm population were analysed to elucidate the distribution of mast cells. Nodules with live females were classified according to the presence or absence of microfilariae. Immunohistochemical staining was performed using antibodies specific for mast cells or IgE. Mast cells appeared singly or in diffuse accumulations perivascularly and in inflammatory infiltrates between adult Onchocerca volvulus and in the capsular area. No mast cells were detected in cystic parts. Only few, scattered mast cells were found in the fibrous zone around the adult worm. They were increased with stronger infiltration and hence, related to the inflammatory cells. Mast cells were never localized directly at adult worms or microfilariae. A correlation of the mast cell distribution to the occurrence of eosinophils was observed regarding higher numbers of mast cells and eosinophils in nodules with microfilariae-producing females. Nodules with single males revealed higher numbers of mast cells than nodules with non-producing females, although both contained very few eosinophils. Onchocercomata with dead worms contained significantly more mast cells than those with live filariae. In conclusion, the localization and frequency o...Continue Reading

Citations

Sep 29, 2009·Parasitology Research·Sabine SpechtDietrich W Büttner
May 22, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bita ShakooryGuha Krishnaswamy
Sep 19, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Fernandez-Flores, Antonio Alija
Jun 13, 2003·Filaria Journal·Dietrich W BüttnerPeter Fischer
Jan 9, 2009·The Journal of Parasitology·G GrandiF Simon
Jan 13, 2000·Experimental Parasitology·G Salinas, S Cardozo
Dec 17, 1998·Tropical Medicine & International Health : TM & IH·G WildenburgD W Büttner
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabine SpechtAchim Hoerauf

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