Mast cell function is not altered by Coronin-1A deficiency.

Journal of Leukocyte Biology
Sanja ArandjelovicKerri A Mowen

Abstract

Coronin-1A is a WD repeat protein family member, highly expressed in all hematopoietic lineages, and acts as a regulator of F-actin dynamics and Ca2+ signaling. In Coro1a(Lmb3) mice results in inactivation of the protein and leads to disease resistance in a model of lupus erythematosus. In Coro1a(-/-) and Coro1a(Lmb3) mice, peripheral T cells exhibit impairments in survival, migration, activation, and Ca2+ flux. In this study, we show that in vitro-differentiated mast cells from Coro1a(Lmb3) mice are viable, developed normally, and are fully functional in assays of degranulation, cytokine secretion, and chemotactic migration, despite increased F-actin levels. In Coro1a(Lmb3) mast cells, Ca2+ flux in response to physiological FcεRI stimulation is unaffected. Finally, Coro1a(Lmb3) mice showed similar in vivo mast cell responses as the WT mice. Coronin-1B and Coronin-1C expression levels were not increased in Coro1a(Lmb3) mast cells but were higher in mast cells than in CD4 T cells or B cells in WT mice. We conclude that Coronin-1A activity is not required for mast cell function.

References

Jan 1, 1986·International Archives of Allergy and Applied Immunology·N InagakiA Koda
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori
May 16, 2000·The Journal of Allergy and Clinical Immunology·C M Williams, S J Galli
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·T P StosselS S Shapiro
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B T Wipke, P M Allen
Dec 18, 2001·European Journal of Immunology·L SmurthwaiteH J Gould
Oct 3, 2002·Nature Reviews. Immunology·Toshiaki Kawakami, Stephen J Galli
Apr 25, 2003·The New England Journal of Medicine·David E Woolley
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather A CokerHannah J Gould
May 27, 2004·European Journal of Immunology·Helena TolarováPetr Dráber
Oct 2, 2004·Nature Reviews. Immunology·Jean S Marshall
Dec 14, 2004·Nature Structural & Molecular Biology·Avital A RodalBruce L Goode
Apr 15, 2005·Molecular Biology of the Cell·Ming YanWilliam S Trimble
May 14, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Vasily Rybakin, Christoph S Clemen
Feb 14, 2006·Nature Reviews. Immunology·Alasdair M Gilfillan, Christine Tkaczyk
Jun 9, 2006·Immunologic Research·Yoshimichi Okayama, Toshiaki Kawakami
Jun 30, 2006·Trends in Cell Biology·Andrea C Uetrecht, James E Bear
Oct 25, 2006·The Journal of Cell Biology·William M BrieherTimothy J Mitchison
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming YanWilliam S Trimble
Jan 18, 2008·Immunity·M Katarina HaraldssonDwight H Kono
Dec 18, 2008·Nature Immunology·Monika Vig, Jean-Pierre Kinet
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benoit CombaluzierJean Pieters
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benoit Combaluzier, Jean Pieters
Dec 17, 2009·Autoimmunity·Dilki C WickramarachchiDwight H Kono

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Citations

Jun 15, 2013·Nature Reviews. Immunology·Jean PietersRajesh Jayachandran
Apr 18, 2015·International Immunopharmacology·Rajesh Jayachandran, Jean Pieters
Sep 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanja ArandjelovicKerri A Mowen
Aug 28, 2016·The Journal of Biological Chemistry·Kerstin SiegmundGottfried Baier
Oct 9, 2016·Immunobiology·Vincent Sam Yong TchangJean Pieters

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