PMID: 7520725Jan 1, 1993Paper

Mast cell growth factor (C-kit ligand) in combination with granulocyte-macrophage colony-stimulating factor and interleukin-3: in vivo hemopoietic effects in irradiated mice compared to in vitro effects

Biotherapy
M L PatchenD E Williams

Abstract

In the presence of hemopoietic cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem cell factor, and c-kit ligand) has proven to be a potent hemopoietic regulator in vitro. In these studies, we examined the in vivo effects of MGF in combination with GM-CSF or GM-CSF plus IL-3. Effects were based on the ability of these cytokines to stimulate recovery from radiation-induced hemopoietic aplasia. Female B6D2F1 mice were exposed to a sublethal 7.75-Gy dose of 60Co radiation followed by subcutaneous administration of either saline, recombinant murine (rm) MGF (100 micrograms/kg/day), rmGM-CSF (100 micrograms/kg/day), rmIL-3 (100 micrograms/kg/day), or combinations of these cytokines on days 1-17 postirradiation. Recoveries of bone marrow and splenic spleen colony-forming units (CFU-s), granulocyte macrophage colony-forming cells (GM-CFC), and peripheral white blood cells (WBC), red blood cells (RBC) and platelets (PLT) were determined on days 14 and 17 during the postirradiation recovery period. MGF administered in combination with GM-CSF or in combination with GM-CSF plus IL-3 either produced no greater response than GM-C...Continue Reading

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Citations

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L Patchen
Jul 20, 2002·Leukemia Research·Patricia AultHagop Kantarjian
Feb 17, 2005·Experimental and Molecular Pathology·Vijay K Singh, Virendra S Yadav
Oct 16, 2014·Expert Opinion on Therapeutic Patents·Vijay K SinghThomas M Seed
May 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferMartin Falk
Aug 3, 2005·Journal of Experimental Botany·David Stuart Thompson
Jun 26, 1998·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·H A SchumacherD Drescher
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J SmithAntonio C Wolff
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·J W Freston
Jan 16, 2009·Experimental Biology and Medicine·Hong LinSusanna Cunningham-Rundles
Apr 4, 2012·Radiation Research·Lynnette H CaryMark H Whitnall
Jul 18, 2014·PLoS Neglected Tropical Diseases·Michael F MinnickRichard J Birtles
Sep 3, 2013·International Journal of Rheumatic Diseases·Naomi SuzukiTakashi Sawai
Aug 18, 2021·International Journal of Radiation Biology·Vijay K Singh, Thomas M Seed

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