Mast cell mediator release in nonasthmatic subjects after endobronchial adenosine challenge

The Journal of Allergy and Clinical Immunology
Fionnuala CrummyL G Heaney

Abstract

Adenosine 5'-monophosphate (AMP) has been shown to cause bronchoconstriction in atopic subjects but to have no effect on nonatopic nonasthmatic subjects. Endobronchial AMP challenge has previously been shown to cause mast cell mediator release in asthmatic subjects, but it is unknown whether a similar response occurs in atopic nonasthmatic and nonatopic nonasthmatic control subjects who have no response to inhalation AMP challenge. This study examined the change in mast cell-derived products after endobronchial saline challenge and AMP challenge in subjects with and without a positive inhalation response to AMP. Inhalation challenge with AMP challenge was performed in normal, atopic nonasthmatic, and atopic asthmatic subjects. Levels of mast cell mediators were measured after endobronchial adenosine challenge and after placebo endobronchial saline challenge. There were significant increases in histamine, tryptase, protein, and prostaglandin D2 levels (P=.02, P=.02, P=.01, and P=.01, respectively) after AMP challenge compared with after saline challenge in nonatopic nonasthmatic subjects. There was no significant increase in any mediator in either of the other 2 groups. This study suggests dissociation between mediator release a...Continue Reading

References

May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Nov 1, 1988·The American Review of Respiratory Disease·P T PeachellG Marone
Jul 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G D PhillipsS T Holgate
Nov 1, 1987·British Journal of Clinical Pharmacology·A H WattA H Henderson
Nov 1, 1987·The American Review of Respiratory Disease·A S Buist
Feb 1, 1983·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·R PolosaA Mistretta
Jul 1, 1993·The American Review of Respiratory Disease·A G DriverS J Mustafa
Feb 1, 1997·The Journal of Allergy and Clinical Immunology·M K Church, F Levi-Schaffer
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·A J AmmitJ L Black
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T Holgate
Nov 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KoshinoY Morita
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C E BrightlingI D Pavord
May 31, 2002·The New England Journal of Medicine·Christopher E BrightlingIan D Pavord

❮ Previous
Next ❯

Citations

Feb 3, 2005·Current Allergy and Asthma Reports·Sandra D Anderson, Pascale Kippelen
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Fionnuala CrummyLiam G Heaney
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Daniel PohlKai Michael Beeh
Aug 30, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Yoshimichi OkayamaChisei Ra
Oct 25, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K J DacreA D Pemberton
Jan 25, 2006·British Journal of Pharmacology·Sandra KeirClive Page
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Yoseph A Mekori
Nov 7, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Sumito IsogaiKazuyoshi Imaizumi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.