Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice.

Pain Reports
Carolina B MelotoLuda Diatchenko

Abstract

Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. We aimed to test the effect of treatment with KF in pain assays in mice and in a case series of patients with chronic widespread pain. The analgesic effect of KF was tested in CD-1 mice injected with formalin, complete Freund's adjuvant, or subjected to spared nerve injury. In addition, wild-type (C57BL/6) and MC-deficient (C57BL/6-Kit W-sh/W-sh) mice were injected with formalin or complete Freund's adjuvant and treated with KF. Patients with chronic widespread pain (n = 5; age: 13-16 years) who failed to respond to standard of care participated in a 16-week treatment trial with KF (6 mg/d). Ketotifen fumarate's therapeutic effect was evaluated using the patient global impression of change. In the mouse experiments, KF produced dose- and MC-dependent analgesic effects against mechanical allodynia in the acute and chronic inflammatory pain but not neuropathic pain assays. In the patient case series, 4 patients reported that activity limitations, symptoms, emotions, and overall quality of life related to their pain condition were "...Continue Reading

References

Jan 1, 1985·Respiration; International Review of Thoracic Diseases·L Nagy, M Orosz
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·L P Craps
Mar 1, 1982·Clinical Allergy·R V HeatleyJ Bienenstock
Dec 1, 1994·The European Journal of Neuroscience·G R LewinL M Mendell
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jan 1, 1996·European Journal of Clinical Pharmacology·J OckengaI Schedel
Aug 2, 2003·Journal of the American Academy of Dermatology·Tomoyuki OhtaniHachiro Tagami
Mar 1, 1957·Journal of the American Pharmaceutical Association·N W DUNHAM, T S MIYA
Jul 14, 2004·Gynecologic and Obstetric Investigation·Jacob BornsteinEdmund Sabo
Jan 5, 2005·Digestive Diseases and Sciences·Fusun F BolukbasEbru Ozturk
Mar 5, 2005·BMC Gastroenterology·Willemijntje A HoogerwerfPankaj J Pasricha
Jun 10, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chih-Hsing HungKuender D Yang
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
Dec 24, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G BarbaraR Corinaldesi
Sep 20, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Grazyna GalatowiczVirginia L Calder
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jacob BornsteinElla Ophir
Jan 29, 2008·Life Sciences·Katsuyo OhashiYoichi Kurebayashi
Feb 8, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mary C TobinAli Keshavarzian
May 8, 2008·PloS One·Charles N RudickDavid J Klumpp
Jun 20, 2008·The Journal of Pain : Official Journal of the American Pain Society·Patrick J McGrathUNKNOWN PedIMMPACT
Oct 10, 2009·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Hugh J Freeman
Oct 15, 2009·Annals of Epidemiology·Bernard L HarlowRuby H N Nguyen
Nov 17, 2009·BMC Urology·Charles N RudickDavid J Klumpp
Apr 20, 2010·The Journal of Pain : Official Journal of the American Pain Society·Chan-Jin ChoiSynnove Fonnebo Knutsen
Apr 30, 2010·Clinical Rheumatology·Ignacio BlancoMorley D Hollenberg
May 1, 2010·American Journal of Obstetrics and Gynecology·Martha F GoetschCatherine M Leclair
Apr 15, 2011·British Journal of Haematology·Katia Stankovic StojanovicFrançois Lionnet
Oct 19, 2011·European Journal of Pharmacology·Sara Marchesan OliveiraJuliano Ferreira
Nov 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Anne E SandersGary D Slade
Nov 29, 2011·Immunity·Howard R Katz, K Frank Austen
Feb 22, 2012·The Journal of Urology·Joseph D DonePraveen Thumbikat
Jul 26, 2012·Biochemical and Biophysical Research Communications·Devavani ChatterjeaTijana Martinov
Feb 28, 2013·British Journal of Pharmacology·D F Finn, J J Walsh
Mar 5, 2013·The Journal of Pain : Official Journal of the American Pain Society·Alison PepperJ David Clark
Mar 22, 2013·World Journal of Gastrointestinal Pathophysiology·Wendy A HendersonNader N Youssef

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