Mast cell transcriptional networks.

Blood Cells, Molecules & Diseases
Clifford TakemotoMichael A McDevitt

Abstract

Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J FujitaY Kanakura
Sep 1, 1987·Journal of Cellular Physiology·D J StechschulteR L Jilka
Jun 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J Stevens, J F Loutit
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·G Henkel, M A Brown
Nov 1, 1995·Trends in Genetics : TIG·K J Moore
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·K OnoderaM Yamamoto
May 9, 1997·The Journal of Biological Chemistry·S TakahashiM Yamamoto
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A McDevittS H Orkin
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A McDevittS H Orkin
Mar 7, 1998·The Journal of Biological Chemistry·N MinegishiM Yamamoto
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·G A BlobelS H Orkin
May 15, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·H HarigaeM Yamamoto
Jul 25, 1998·Genes and Function·A RonchiS Ottolenghi
Oct 24, 1998·The Journal of Biological Chemistry·E O BockampA R Green
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·K E BoydP J Farnham
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·P ZhangZ Sun
Aug 7, 1999·The Journal of Biological Chemistry·J H KoN Taniguchi
May 16, 2000·The Journal of Biological Chemistry·D SeshasayeeD M Wojchowski
Mar 27, 2001·Nature Reviews. Genetics·S H Orkin
Jul 13, 2001·Nature·H GuB G Neel
Sep 5, 2001·Current Opinion in Genetics & Development·A B Cantor, S H Orkin
Oct 18, 2001·The Journal of Biological Chemistry·K I ZellerC V Dang
Nov 7, 2001·The Journal of Experimental Medicine·M F GurishK F Austen
Jan 29, 2002·Biochemical and Biophysical Research Communications·Keisuke ObokiYukihiko Kitamura

❮ Previous
Next ❯

Citations

May 21, 2010·Journal of Pediatric Hematology/oncology·Cliff Takemoto
Feb 9, 2010·The Tohoku Journal of Experimental Medicine·Kibom KimMasayuki Yamamoto
Aug 5, 2014·Current Allergy and Asthma Reports·Hua Huang, Yapeng Li
Sep 10, 2014·Experimental Hematology·Sun Young OhClifford M Takemoto
Mar 15, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Haruka SasakiTomohiko Tamura
Mar 7, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasushi IshijimaKinuko Ohneda
Oct 24, 2012·Experimental Dermatology·Chang Ook ParkKwang Hoon Lee
May 1, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Misa KiuchiKazuo Komiyama
Nov 26, 2008·Stem Cells and Development·Barbara GhinassiAnna Rita Migliaccio
Jan 18, 2011·Biochimica Et Biophysica Acta·Sagi Tshori, Hovav Nechushtan
Apr 30, 2016·Seminars in Immunopathology·Hua HuangBing Liu
Apr 15, 2008·Blood Cells, Molecules & Diseases·Clifford M TakemotoMichael A McDevitt
Mar 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yapeng LiHua Huang
Aug 2, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sai ZhangDerek B Sant'Angelo
Mar 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clifford M TakemotoMichael A McDevitt
Nov 5, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maria-Angeles AllerJaime Arias
Jul 6, 2014·British Journal of Haematology·Tugce B BalciJason N Berman
Jan 1, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hanliang SunZhaojin Wang
Dec 19, 2020·Frontiers in Immunology·Kazushige Obata-NinomiyaSteven F Ziegler
Jun 29, 2021·Journal of Scleroderma and Related Disorders·Kevin TomMonique Hinchcliff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved