PMID: 20126998Feb 4, 2010Paper

Mast cell tryptase promotes breast cancer migration and invasion

Oncology Reports
Meng XiangLianhua Yin

Abstract

It has been reported that the number of typtase-positive mast cells was significantly greater in breast peritumoral tissue. However, the significance of tryptase in tumor growth and metastasis is unknown. Tryptase in surgical breast cancer samples was stained by immunohistochemistry. The effects of tryptase on breast cancer proliferation, invasion and migration were observed in vitro. We found significantly more tryptase in peritumoral tissue than in normal breast tissue. The increased tryptase was associated with higher tumor grade and more lymph node metastasis. Tryptase promoted the invasion and migration of breast cancer cells along with activation of matrix metalloproteinase-2. Tryptase did not affect the proliferation of the cells. Our results indicate that tryptase promotes breast cancer migration and invasion.

Citations

Jan 27, 2011·Cancer Metastasis Reviews·Jing LiuBo Huang
Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
Feb 11, 2012·Clinical & Experimental Metastasis·Daniela Spano, Massimo Zollo
Mar 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Heath A Smith, Yibin Kang
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Neta Erez, Lisa M Coussens
Dec 12, 2017·F1000Research·Gerhard J MolderingsLawrence B Afrin
Mar 21, 2017·Virchows Archiv : an International Journal of Pathology·Anna GlajcarKrzysztof Okoń
Dec 17, 2020·Cells·Joanna PastwińskaJarosław Dastych

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