Mast cell ultrastructure in the inferior turbinate and stroma of nasal polyps

The Journal of Laryngology and Otology
A Drake-Lee, J Price

Abstract

Fourteen unselected adult patients with nasal polyps had ultrastructural examination of mast cells from matching biopsies of the polyp and inferior turbinate. Between three and 10 blocks were examined for each patient in both tissues and every mast cell that had a nucleus was photographed for study. Fifty-three mast cells were found within the stroma of nasal polyps and 54 in the submucosa of the inferior turbinate biopsies. The number of granules ranged between 13 and 167 (mean 60) for polyps and 18 and 148 (mean 61) in the inferior turbinate. The mast cells appeared essentially normal in the inferior turbinate of four patients. The degree of degranulation of the mast cells was calculated as in previous studies and then averaged for both the polyp and the inferior turbinate of each patient. There was greater degranulation in the nasal polyp compared to inferior turbinate (p = 0.03). These results were compared with mast cell degranulation found in the normal nose and in the inferior turbinate of patients with perennial allergic rhinitis which we previously published. The inferior turbinates in these patients were more degranulated than the normal nose (p = 0.0001) but were similar to that found in patients with perennial aller...Continue Reading

References

Jan 1, 1977·The Journal of Allergy and Clinical Immunology·G A Settipane, F H Chafee
Dec 1, 1991·The Journal of Laryngology and Otology·A B Drake-Lee, J Price
Aug 1, 1984·The Journal of Laryngology and Otology·A B Drake-LeeA Grace
Feb 1, 1994·Clinical and Experimental Immunology·S FinottoJ S Marshall
Mar 1, 1996·The Journal of Laryngology and Otology·A Drake-LeeD Stanworth
Oct 1, 1996·The Journal of Laryngology and Otology·A SlaterA B Drake-Lee

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Citations

Feb 25, 2011·International Archives of Allergy and Immunology·Claus Bachert
Sep 17, 2009·Immunological Reviews·Joseph Di Capite, Anant B Parekh
Dec 19, 2015·The Annals of Otology, Rhinology, and Laryngology·Xiaoyang HuaStephen L Tilley
Mar 4, 2006·Treatments in Respiratory Medicine·Niels Mygind, Valerie Lund
Jan 2, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Richa GuptaV K Poorey
Jun 30, 2019·The Journal of Allergy and Clinical Immunology·Stephen M HayesRami J Salib
Nov 9, 2000·American Journal of Rhinology·C BachertP van Cauwenberge

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