Mast cells acquire MHCII from dendritic cells during skin inflammation

The Journal of Experimental Medicine
Jan DudeckAnne Dudeck

Abstract

Mast cells (MCs) and dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces. Using longitudinal intravital multiphoton microscopy of DCGFP/MCRFP reporter mice, we herein provide in vivo evidence that migratory DCs execute targeted cell-to-cell interactions with stationary MCs before leaving the inflamed skin to draining lymph nodes. During initial stages of skin inflammation, DCs dynamically scan MCs, whereas at a later stage, long-lasting interactions predominate. These innate-to-innate synapse-like contacts ultimately culminate in DC-to-MC molecule transfers including major histocompatibility complex class II (MHCII) proteins enabling subsequent ex vivo priming of allogeneic T cells with a specific cytokine signature. The extent of MHCII transfer to MCs correlates with their T cell priming efficiency. Importantly, preventing the cross talk by preceding DC depletion decreases MC antigen presenting capacity and T cell-driven inflammation. Consequently, we identify an innate intercellular communication arming resident MCs with key DC functions that might contribute to the acute defense potential during critical periods of migration-based DC absence.

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Citations

Apr 5, 2018·Seminars in Immunopathology·Tom Groot KormelinkMarca H M Wauben
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Dec 2, 2020·Cells·Konstantinos Katsoulis-DimitriouAnne Dudeck
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Feb 14, 2021·The Journal of Allergy and Clinical Immunology·Tomoko HiranoKenji Kabashima
May 1, 2021·International Journal of Molecular Sciences·Martin VossAnne Dudeck
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Methods Mentioned

BETA
Fluorescence
flow cytometry
protein exchange
lavage
FCS

Software Mentioned

FlowJo Analysis
MacsQuant
Imaris
ImageJ
Fiji
Iterative Deconvolve
Python

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