Mast cells: an expanding pathophysiological role from allergy to other disorders.

Naunyn-Schmiedeberg's Archives of Pharmacology
Preet AnandNirmal Singh

Abstract

The mast cells are multi-effector cells with wide distribution in the different body parts and traditionally their role has been well-defined in the development of IgE-mediated hypersensitivity reactions including bronchial asthma. Due to the availability of genetically modified mast cell-deficient mice, the broadened pathophysiological role of mast cells in diverse diseases has been revealed. Mast cells exert different physiological and pathophysiological roles by secreting their granular contents, including vasoactive amines, cytokines and chemokines, and various proteases, including tryptase and chymase. Furthermore, mast cells also synthesize plasma membrane-derived lipid mediators, including prostaglandins and leukotrienes, to produce diverse biological actions. The present review discusses the pathophysiological role of mast cells in different diseases, including atherosclerosis, pulmonary hypertension, ischemia-reperfusion injury, male infertility, autoimmune disorders such as rheumatoid arthritis and multiple sclerosis, bladder pain syndrome (interstitial cystitis), anxiety, Alzheimer's disease, nociception, obesity and diabetes mellitus.

References

Sep 1, 1992·Neurochemical Research·D Johnson, W Krenger
Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
Dec 1, 1991·Journal of Clinical Pathology·D Heath, M Yacoub
Sep 1, 1989·Gastroenterology·R H SteadJ Bienenstock
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J O Kokkonen, P T Kovanen
May 1, 1982·Journal of Cardiovascular Pharmacology·S R JollyB R Lucchesi
May 1, 1980·The Journal of Investigative Dermatology·L B Schwartz, K F Austen
Jun 1, 1982·Genetical Research·M F Lyon, P H Glenister
Jul 1, 1995·British Journal of Urology·W BoucherT C Theoharides
Jan 1, 1995·Annals of Neurology·J J RoznieckiT C Theoharides
Aug 1, 1994·The Journal of Urology·M el-MansouryT C Theoharides
Jan 1, 1993·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P M LehrerS M Hochron
Oct 1, 1996·Cardiovascular Research·P Kubes, D N Granger
Nov 1, 1996·The Journal of Allergy and Clinical Immunology·E W Alton, A A Norris
Dec 1, 1996·Southern Medical Journal·A J Pedinoff
Sep 1, 1997·The Journal of Urology·D R EricksonD J Dabbs
May 27, 1999·Thorax·Y MitaniM Sakurai
Aug 12, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E KakizoeH Okunishi
Mar 8, 2000·The Journal of Experimental Medicine·V H SecorM A Brown
Mar 24, 2000·International Archives of Allergy and Immunology·M MiyataR Kasukawa
Jul 8, 2000·The European Respiratory Journal·A ImadaS Abe
Mar 28, 2001·Annals of the New York Academy of Sciences·A J Dunn
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K A LindstedtP T Kovanen
Jul 10, 2001·The Journal of Investigative Dermatology·H HegyesiZ Darvas
Oct 17, 2001·The Journal of Clinical Investigation·R ChenZ Liu
Dec 18, 2001·Cardiovascular Research·Nikolaos G FrangogiannisMark L Entman

❮ Previous
Next ❯

Citations

Sep 26, 2012·Journal of Periodontology·Takeshi Kato SegundoRicardo Alves Mesquita
Dec 12, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lixin KanJohn A Kessler
Feb 19, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Franziska SchmerseAna Claudia Zenclussen
Nov 6, 2015·International Journal of Molecular Sciences·Min-Kyung JangMyeong Ho Jung
Nov 12, 2015·Cutaneous and Ocular Toxicology·Zeynep DadaciMehmet Borazan
Nov 19, 2015·Parasite Immunology·Krisztina V VukmanSandra M O'Neill
Jun 13, 2015·International Journal of Legal Medicine·Barbara MuciacciaRossana Cecchi
Sep 3, 2013·Cell Biochemistry and Function·Qiyan LiZhiqiang Pan
May 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandra GraziottinMariella Fusco
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
Oct 16, 2013·Journal of Neuroimmunology·Anne Héron, David Dubayle
May 2, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Gerhard J MolderingsLawrence B Afrin
Aug 13, 2014·Journal of Lipid Research·Andrea DichlbergerPetri T Kovanen
Dec 23, 2015·International Journal of Molecular Sciences·Anupam AichKalpna Gupta
Feb 13, 2018·Frontiers in Systems Neuroscience·Isabella M Fuentes, Julie A Christianson
May 22, 2019·Journal of Neuroinflammation·Juan Antonio FloresEva Alés
Dec 22, 2012·Expert Review of Clinical Immunology·Lianne BeunkGer T Rijkers
Jul 9, 2017·Reviews in the Neurosciences·Gunjanpreet KaurAmteshwar Singh Jaggi
Jun 21, 2019·Immunology·Paulina ŻelechowskaJustyna Agier
May 8, 2020·Cells·Md Abdul AlimGunnar Pejler
Apr 5, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiyuki AkiyamaYukio Homma
Jan 13, 2015·International Journal of Immunopathology and Pharmacology·E SpinasP Conti
Sep 17, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Amteshwar Singh JaggiNirmal Singh
Jul 19, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Paulina ŻelechowskaEwa Brzezińska-Błaszczyk
Aug 14, 2019·International Journal of Molecular Sciences·Edismauro Garcia Freitas FilhoMaria Célia Jamur
Dec 28, 2016·Clinical Reviews in Allergy & Immunology·Daniel Elieh-Ali-Komi, Yonghao Cao
Apr 16, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Yukio HommaKyu-Sung Lee
Feb 29, 2020·Journal of Family Medicine and Primary Care·Fatemeh RezaeiFarzad Rezaei
Mar 1, 2018·Frontiers in Cellular Neuroscience·Olivia C Eller-SmithJulie A Christianson
Jun 17, 2021·Lower Urinary Tract Symptoms·Russ Chess-WilliamsKylie A Mills
May 11, 2013·Journal of Medicinal Chemistry·Steven J TaylorHidenori Takahashi

❮ Previous
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