Mast cells and angiogenesis in canine melanomas: malignancy and clinicopathological factors

Veterinary Dermatology
Sydney MukaratirwaNdumiso Moyo

Abstract

The biological significance of mast cells and angiogenesis in canine melanomas is unclear. Eighty canine melanomas (56 malignant and 24 benign), investigated to determine the relationship between mast cell count (MCC), microvessel density (MVD) and clinicopathology, revealed significantly higher MCC and MVD counts in malignant melanomas. Evaluation of the prognostic significance of MCC and MVD in malignant melanomas showed a significant correlation between MCC and MVD both within and at the edges of the tumour. Multivariate analysis indicated that MCC and MVD were independent predictors of survival but the former was a significantly better prognostic marker. Greater numbers of mast cells and microvessels were found in malignant melanomas of poor prognosis. The findings demonstrate a prognostic significance of MCC and MVD in canine melanocytic tumours.

References

Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·D A KesslerJ Folkman
Aug 1, 1992·Plastic and Reconstructive Surgery·L W LuriaN Fenske
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·J R StarkeyS Taubenberger
Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·J P KankkunenA Naukkarinen
Mar 21, 1998·Journal of Cutaneous Pathology·L M DuncanM C Mihm
Sep 28, 1999·Journal of Veterinary Internal Medicine·J C Graham, R K Myers
Jul 8, 2000·The European Respiratory Journal·A ImadaS Abe
Jul 13, 2000·The Annals of Thoracic Surgery·M TomitaT Onitsuka
Sep 13, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M TomitaT Onitsuka
Nov 27, 2002·Veterinary Pathology·S H SmithP M McManus
Mar 26, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Anak IamaroonSitthichai Wanachantararak
May 23, 2003·European Journal of Clinical Investigation·D RibattiP Sirigu
Apr 1, 1955·Journal of Comparative Pathology·E COTCHIN
Mar 9, 2004·Journal of Comparative Pathology·R PreziosiM Paltrinieri
Nov 17, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RibattiA Vacca

❮ Previous
Next ❯

Citations

Feb 4, 2010·Veterinary Research Communications·Moges Woldemeskel, Sreekumari Rajeev
Jul 11, 2006·Veterinary Dermatology·Emily J Walder
Nov 15, 2011·Veterinary and Comparative Oncology·A SfacteriaG Mazzullo
Apr 24, 2012·Journal of Comparative Pathology·M C CuitiñoJ R Idiart
Jul 16, 2014·The Veterinary Quarterly·Fabrizio GrandiNoeme S Rocha
Dec 19, 2019·Arkhiv patologii·S V SaakyanE B Myakoshina
Jan 1, 2014·SAGE Open Medicine·Moges WoldemeskelLisa Whittington

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.