Mast cells and angiogenesis in pancreatic ductal adenocarcinoma.

Clinical and Experimental Medicine
Vito LongoDomenico Ribatti

Abstract

Mast cells are recognized as critical components of the tumor stromal microenvironment in several solid and hematological malignancies, promoting angiogenesis and tumor growth. A correlation between mast cells infiltration, angiogenesis and tumor progression has been reported for pancreatic ductal adenocarcinoma as well. Mast cells contribute to the aggressiveness of the pancreatic ductal carcinoma enhancing the expression of several pro-angiogenic factors such as vascular endothelial growth factor, fibroblast growth factor-2, platelet-derived growth factor and angiopoietin-1 as well as stimulating the pancreatic cancer cells proliferation by IL-13 and tryptase. The disruption of this pro-angiogenic and proliferative stimulation by inhibiting the mast cells migration and degranulation is under investigation as a potential therapeutic approach in pancreatic ductal adenocarcinoma patients. This review will summarize the literature concerning the mast cells infiltration in the pancreatic ductal adenocarcinoma analyzing its role in angiogenesis and tumor progression.

References

Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerEverett E Vokes
Jan 10, 2006·The American Journal of Pathology·Enrique ZudaireFrank Cuttitta
May 18, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G CriccoG Martín
May 15, 2007·Immunological Reviews·Jean-Pierre Kinet
Apr 25, 2008·The New England Journal of Medicine·Theoharis C Theoharides
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew J StrouchDavid J Bentrem
Jun 30, 2011·Advances in Experimental Medicine and Biology·Domenico Ribatti, Enrico Crivellato
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David Z ChangPatrick Hwu
May 2, 2013·Cancer Research·Ying MaStephen E Ullrich
Sep 3, 2013·Current Medicinal Chemistry·Nicola SilvestrisMichele Reni
Oct 3, 2013·International Journal of Molecular Sciences·Antonio GnoniNicola Silvestris
Feb 19, 2014·Immunology Letters·Domenico Ribatti, Enrico Crivellato
Feb 27, 2014·Hepatobiliary Surgery and Nutrition·Taylor FrancisHeather Francis
Jul 10, 2014·International Journal of Immunopathology and Pharmacology·E KaramitopoulouT C Theoharides
Jul 27, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elaine Zayas Marcelino da SilvaConstance Oliver
Aug 6, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jonathan HaqqAshley R Dennison
Oct 9, 2014·BioMed Research International·Michele AmmendolaGirolamo Ranieri
Apr 11, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DeplanqueP Hammel
Mar 22, 2016·Experimental Cell Research·Domenico Ribatti
May 31, 2016·International Journal of Molecular Sciences·Xiangjie GuoCairong Gao
Jul 28, 2016·Oncotarget·Vito LongoNicola Silvestris
Feb 13, 2017·Seminars in Cell & Developmental Biology·Krisztina V VukmanEdit I Buzás
Apr 28, 2017·Frontiers in Immunology·Gilda VarricchiFrancescopaolo Granata
Jun 13, 2017·Critical Reviews in Oncology/hematology·Anca Maria CimpeanDomenico Ribatti
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DeplanqueP Hammel

❮ Previous
Next ❯

Citations

Apr 25, 2019·International Journal of Molecular Sciences·Gilda VarricchiGianni Marone
May 30, 2019·International Journal of Molecular Sciences·Yaara Gorzalczany, Ronit Sagi-Eisenberg
May 16, 2018·Journal of Molecular Histology·Roberto TammaDomenico Ribatti
Jan 27, 2019·International Journal of Molecular Sciences·Domenico RibattiAngelo Vacca
Jan 11, 2020·Frontiers in Oncology·Wei MuMargot Zöller
Jul 29, 2020·Frontiers in Immunology·Moritz F EissmannMatthias Ernst
Jul 25, 2019·Frontiers in Cellular Neuroscience·Justin RichardsDevina Purmessur
Jun 4, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Katsuya GunjigakeSachio Fushida
May 20, 2020·Therapeutic Advances in Medical Oncology·Tianqi SuJiannan Li
Apr 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Hemanth K KandikattuAnil Mishra
Jul 16, 2021·Life Sciences·Elham BaghbaniBehzad Baradaran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.