Mast cells and resistance to peritoneal sepsis after burn injury

Shock
Odhran ShelleyMary L Rodrick

Abstract

A mouse model of burn injury demonstrates increasing mortality to an infectious challenge in the form of cecal ligation and puncture (CLP) reaching a peak at 10 days after injury. Because it is widely believed that peritoneal mast cells play an important role in the defense against peritoneal sepsis, we wished to explore the possibility that peritoneal mast cell dysfunction contributed to increased CLP mortality after burn injury. Kit(W-v) C57BL/6 mice, which were shown to lack peritoneal mast cells by cytospin and flow cytometry, and normal littermate control animals were subjected to 25% burn or sham burn injury and 10 days later underwent CLP. Burn injured Kit(W-v) and normal littermates had a high CLP mortality when compared with sham-injured Kit(W-v) and normal littermates (P < 0.003), but the sham- and burn-injured Kit(W-v) and normal littermate animals did not differ from one another with respect to CLP mortality. This result prompted a comparison of CLP mortality in untreated WBB6F1 Kit(W/W-v) mice, known to be mast cell deficient, and normal littermate controls, as well as untreated C57BL/6 Kit(W-v) and normal littermates. The WBB6F1 Kit(W/W-v) mice showed significantly increased mortality after CLP as compared with th...Continue Reading

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Oct 24, 2002·Shock·Dylan StewartAntonio De Maio

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Citations

Nov 14, 2007·The Journal of Experimental Medicine·Joseph S ZhouHoward R Katz
Jun 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Priya DedhiaWarren S Pear
Feb 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Silvia PiconeseRosetta Pedotti
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna Di NardoRichard L Gallo
May 15, 2007·Immunological Reviews·Odile Malbec, Marc Daëron

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