Mast cells are required for phototolerance induction and scratching abatement

Experimental Dermatology
Nina A SchweintzgerPeter Wolf

Abstract

Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We administered single UV exposures as well as a chronic UV irradiation regime to mast cell-deficient Kit(W-Sh/W-Sh) mice and their controls. The chronic irradiation protocol was similar to that given for prophylaxis in certain photodermatoses in humans. Compared to controls, UV-exposed Kit(W-Sh/W-Sh) mice were more susceptible to epidermal hyperplasia and dermal oedema which was linked to blood vessel dilation. Unexpectedly, Kit(W-Sh/W-Sh) mice exhibited an excessive scratching behaviour following broadband UVB plus UVA or solar simulated UV irradiation at doses far below their minimal skin-swelling dose. Protection from this UV-induced scratching phenotype was dependent on mast cells, as engraftment of bone marrow-derived cultured mast cells abated it entirely. Kit(W-Sh/W-Sh) mice were entirely resistant to phototolerance induction by photohardening treatment. Compared to controls, these mice also showed reduced numbers of...Continue Reading

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Citations

Mar 17, 2018·Endocrinology·Andrzej T SlominskiRalf Paus
Jul 6, 2017·Experimental Dermatology·Hanna SiiskonenMarcus Maurer
Jul 26, 2019·Experimental Dermatology·Franz J Legat
Jul 5, 2016·Experimental Dermatology·Peter WolfScott N Byrne
Dec 19, 2018·Frontiers in Medicine·Franz J Legat
Dec 2, 2017·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giovanni PaolinoStefano Calvieri

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