PMID: 9159215Feb 15, 1997Paper

Mast cells as modulators of host defense in the lung

Frontiers in Bioscience : a Journal and Virtual Library
S N AbrahamR Malaviya

Abstract

Mast cells display a distinct spatial distribution in the lung where they are found preferentially in intraepithelial locations or in deeper tissue around blood vessels, bronchioles and mucus secreting glands. Yet the physiological role of these granule-laden cells is unknown. There are now intriguing signs that their distinctive distribution together with their intrinsic capacity to release large amounts of inflammatory mediators serve a critical role in immune surveillance. Mast cells have now been shown to be capable of recognizing and aggressively reacting to a wide range of bacteria. The mast cell responses involve ingesting and killing of adherent bacteria, in a manner not unlike that of traditional phagocytic cells. Concomitant with this endocytic activity, a large variety of potent inflammatory mediators are released by the mast cell. One such mast cell-derived mediator, TNF-alpha, was recently shown to be a critical signal for initiating neutrophil influx to sites of bacterial infection in the lung as well as the peritoneum of mice. This capacity of mast cells to recruit neutrophils, together with its recently reported participation in processing and presenting bacterial antigens to immune cells and in mediating prolif...Continue Reading

Citations

Dec 6, 2003·American Journal of Physiology. Cell Physiology·Derek StrassheimEdward Abraham
Jun 28, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Delphine C MalherbeJo Rae Wright
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jyothi M KetavarapuBernard P Arulanandam
Jun 25, 2013·Journal of Leukocyte Biology·Krisztina V VukmanSandra M O'Neill
Jan 11, 2018·International Journal of Environmental Research and Public Health·Violetta BorelliGiuliano Zabucchi
Sep 27, 2013·International Journal of Immunopathology and Pharmacology·S FrydasF Pandolfi
Nov 4, 2011·Immunologic Research·Jordan Wesolowski, Fabienne Paumet

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