Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability

Radiation Research
Kyung Ran ParkD Fukumura

Abstract

Induction of vascular hyperpermeability is one of the early vascular responses to radiation exposure and is considered to contribute to subsequent fibrosis and tissue injuries. However, the mechanism underlying radiation-induced hyperpermeability has not yet been clearly elucidated. Here, we provide experimental evidence indicating that mast cells contribute to the increase in vascular permeability for albumin in normal mouse skin after irradiation. Vascular permeability in the skin of C3H mice increased after 2, 15 and 50 Gy irradiation, peaked at 24 h after irradiation and gradually decreased thereafter to the baseline level within 3-10 days. Both the extent and duration of hyperpermeability were dose dependent. We found significant degranulation of mast cells in the skin after 15 Gy irradiation. To further investigate the role of mast cells in the radiation-induced increase in vascular permeability, we measured vascular permeability in the skin of mast cell-deficient mice (WW(v)) and their wild-type littermates at 24 h after irradiation. Vascular permeability in WW(v) mice did not change, whereas that in wild-type mice significantly increased after irradiation. There were no appreciable changes in the total tissue levels of ...Continue Reading

References

Nov 1, 1978·International Journal of Radiation Oncology, Biology, Physics·O M SalazarC Scarantino
Nov 1, 1978·The British Journal of Radiology·M P Law, R H Thomlinson
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M M GrahamJ S Rasey
Jan 1, 1988·Pharmacology & Therapeutics·M A Donlon
Jul 1, 1988·International Journal of Radiation Oncology, Biology, Physics·L KrishnanW R Jewell
Jan 1, 1987·Journal of Applied Physiology·J E LoydK L Brigham
Jan 1, 1966·The British Journal of Radiology·B Jolles, R G Harrison
Oct 15, 1967·Experientia·A BaumgartenW J Vagg
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·T Siegal, M R Pfeffer
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T SiegalH Ovadia
Apr 1, 1997·The American Journal of Physiology·Y NozakiK Shimokata
Aug 26, 1998·International Journal of Radiation Biology·W K MacNaughtonM J Miller
Oct 9, 1999·Journal of Neuropathology and Experimental Neurology·M N TsaoC S Wong
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Oct 1, 1956·The American Journal of Physiology·F P CONTEA C UPTON
Jul 7, 2007·International Journal of Radiation Biology·Martin AlbrechtArtur Mayerhofer
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Dorota GabryśChryso Kanthou
Feb 23, 2008·Angiogenesis·Janice A NagyHarold F Dvorak
Nov 6, 2012·International Journal of Radiation Oncology, Biology, Physics·Everett J ModingCristian T Badea
Mar 22, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoyu JiangJoel R Garbow

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Citations

Dec 13, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Lance L Munn
Apr 10, 2018·The British Journal of Radiology·Olivier GuipaudFabien Milliat
Aug 15, 2018·Frontiers in Immunology·Inigo Martinez-ZubiaurreTurid Hellevik
Oct 14, 2021·Molecular Carcinogenesis·Tomoko Yamazaki, Kristina H Young
Oct 28, 2021·International Journal of Radiation Biology·Mariam Ben KacemVincent Paget

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