Mast cells contribute to vasculogenic mimicry in multiple myeloma

Stem Cells and Development
B NicoD Ribatti

Abstract

The angiogenic response is amplified during the induction phase of multiple myeloma (MM) and appears to exert a key role in the development of the disease [1]. Thus, inhibitors of angiogenesis have proven therapeutic potential in the treatment of patients with MM. Angiogenesis induced during the development of MM involves the direct production of proangiogenic cytokines by plasma cells within the marrow microenvironment. Mast cells (MCs) contribute to the the composition of the cellular components of the microenvironment in patients with MM, but their role in the pathophysiology of the disease is not clear. In this report, we used electron and confocal microscopy approaches to investigate the participation of MCs in the formation of the vessel wall in biopsy specimens from patients with MM. Results were compared to those obtained from the biopsy material of patients with a benign lesion, namely monoclonal gammopathy of undetermined significance (MGUS). Our results show that patients with MM exhibit typical tryptase-positive MCs, which interact physically with the endothelial cells (ECs) lining the vascular lumina, perhaps as a result of dysregulated vasculogenic development. This evidence highlights the importance of the stroma...Continue Reading

References

Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Jun 27, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Smith, N Gallagher
Aug 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D RibattiF Dammacco
Nov 17, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RibattiA Vacca
Dec 14, 2004·Stem Cells and Development·Domenico RibattiAngelo Vacca
Dec 17, 2005·Leukemia·A Vacca, D Ribatti

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Citations

Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Jun 9, 2012·The Journal of Biological Chemistry·Youngmi KimDooil Jeoung
Apr 22, 2010·Pharmaceuticals·Domenico Ribatti
Mar 5, 2015·Cancer Investigation·Constantina A PappaMichael G Alexandrakis
May 28, 2014·Thrombosis Research·Domenico RibattiAngelo Vacca
Jul 13, 2012·Molecular Immunology·Youngmi KimDooil Jeoung
Oct 2, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G ShayC C Lynch
Jan 8, 2016·Clinical Therapeutics·Rodanthi VyzoukakiMichael G Alexandrakis
Mar 28, 2009·Leukemia Research·Domenico RibattiStefano Molica
Jun 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria DevetzoglouMichael G Alexandrakis
Feb 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C A PappaM G Alexandrakis
Jul 28, 2012·Blood·Anja RabenhorstKarin Hartmann
Jul 30, 2014·Frontiers in Oncology·Antonino BrunoLorenzo Mortara
May 31, 2016·International Journal of Molecular Sciences·Xiangjie GuoCairong Gao
Dec 17, 2010·World Journal of Gastrointestinal Surgery·Yue-Zu Fan, Wei Sun
Oct 11, 2019·International Journal of Molecular Sciences·Misun KimDooil Jeoung
Jan 23, 2020·International Journal of Molecular Sciences·Roberto Ria, Angelo Vacca
Jun 11, 2020·Journal of Clinical Medicine·Roberto RiaAngelo Vacca
Sep 11, 2017·Current Osteoporosis Reports·Michele MoschettaAldo M Roccaro
Mar 29, 2018·Annals of Hematology·Vanessa DesantisDomenico Ribatti
Jan 27, 2019·International Journal of Molecular Sciences·Domenico RibattiAngelo Vacca
Aug 21, 2019·Frontiers in Oncology·Andrés ValdiviaGareth I Owen
Jun 18, 2016·Oncology Letters·Amalia VartanianAlexander Belyavsky
Jul 14, 2018·International Journal of Molecular Sciences·Domenico Ribatti, Angelo Vacca

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