Mast Cells Exert Anti-Inflammatory Effects in an IL10-/- Model of Spontaneous Colitis

Mediators of Inflammation
E M LennonA J Moeser

Abstract

Mast cells are well established as divergent modulators of inflammation and immunosuppression, but their role in inflammatory bowel disease (IBD) remains to be fully defined. While previous studies have demonstrated a proinflammatory role for mast cells in acute models of chemical colitis, more recent investigations have shown that mast cell deficiency can exacerbate inflammation in spontaneous colitis models, thus suggesting a potential anti-inflammatory role of mast cells in IBD. Here, we tested the hypothesis that in chronic, spontaneous colitis, mast cells are protective. We compared colitis and intestinal barrier function in IL10-/- mice to mast cell deficient/IL10-/- (double knockout (DKO): KitWsh/Wsh × IL10-/-) mice. Compared with IL10-/- mice, DKO mice exhibited more severe colitis as assessed by increased colitis scores, mucosal hypertrophy, intestinal permeability, and colonic cytokine production. PCR array analyses demonstrated enhanced expression of numerous cytokine and chemokine genes and downregulation of anti-inflammatory genes (e.g., Tgfb2, Bmp2, Bmp4, Bmp6, and Bmp7) in the colonic mucosa of DKO mice. Systemic reconstitution of DKO mice with bone marrow-derived mast cells resulted in significant amelioration o...Continue Reading

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Citations

Jun 30, 2019·World Journal of Gastroenterology : WJG·Alaattin Sen, Holger Stark
Jun 17, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Lei TuJiande D Z Chen
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Dec 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Anderson Barbosa BaptistaMaria do Carmo Gouveia Peluzio
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Jun 13, 2020·Journal of Ethnopharmacology·Thalia Del Rosario Loyo CasaoJoão Paulo Viana Leite
Aug 8, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Konstantina KyritsiHeather Francis

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Methods Mentioned

BETA
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SA Biosciences

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