Mast cells have prognostic value in Merkel cell carcinoma

The American Journal of Dermatopathology
Trevor William BeerKevin Murray

Abstract

We examined the role of mast cell infiltrates and other clinical and histological factors in the prognosis of Merkel cell carcinoma. Mast cells were stained immunohistochemically in 36 Merkel cell carcinomas with an antibody to tryptase. The number of stainable cells was quantified within the tumors and surrounding stroma. Other clinical and histological parameters were examined, statistically analyzed, and compared to subsequent clinical course and prognosis. Patient prognosis was worse with higher tumor mast cell numbers (P < 0.002). Prognosis was also found to be adversely affected by the presence of lymphovascular invasion (P = 0.03) and increased tumor size (P = 0.05). Increased mast cells counts, tumor size, and lymphovascular invasion are associated with an adverse prognosis in Merkel cell carcinomas. Evaluation of mast cell infiltrates may provide useful prognostic data and ultimately could assist in selecting patients that require adjuvant treatment in this aggressive form of skin cancer.

References

May 8, 1993·International Journal of Cancer. Journal International Du Cancer·Y TomitaK Matsumoto
Mar 21, 1998·Journal of Cutaneous Pathology·L M DuncanM C Mihm
Mar 21, 1998·Journal of Cutaneous Pathology·H J CarsonJ B Taxy
Nov 3, 1998·The British Journal of Ophthalmology·T W BeerD H Wright
Feb 15, 2001·Archives of Otolaryngology--head & Neck Surgery·A M GillenwaterH Goepfert
Mar 7, 2001·Journal of Cutaneous Medicine and Surgery· Tai PTJ Gilchrist
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·William M Abraham
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·James K BrownIan P Hall
May 23, 2003·European Journal of Clinical Investigation·D RibattiP Sirigu
Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V KoljonenE Tukiainen
Feb 27, 2004·Journal of Cutaneous Pathology·Ryan T MottMichael B Morgan
Mar 27, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shahriar DabiriMalcom Hayes
Dec 4, 2004·American Journal of Clinical Oncology·Tony Y EngT S Herman
Dec 15, 2004·American Journal of Clinical Oncology·Tony Y EngTerence S Herman
Dec 22, 2004·Journal of Surgical Oncology·Nicole C Hodgson
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J AllenDaniel G Coit
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sydney Ch'ngSwee T Tan
Jul 27, 2006·The Australasian Journal of Dermatology·Michael J Veness
Nov 23, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·A L DanceyS Srivastava

❮ Previous
Next ❯

Citations

Apr 25, 2012·Cancer Immunology, Immunotherapy : CII·Dyana K Dalton, Randolph J Noelle
Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
Sep 23, 2008·The American Journal of Dermatopathology·Lydia NgKevin Murray
Nov 27, 2008·The American Journal of Dermatopathology·Angel Fernandez-Flores
Aug 5, 2009·The American Journal of Dermatopathology·Trevor W Beer, Dawn Haig
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew J StrouchDavid J Bentrem
Jan 18, 2012·Neuroendocrinology·Pietro Ameri, Diego Ferone
Oct 21, 2014·Scientifica·Laura Sterian Ward
Dec 12, 2012·Cancer Cytopathology·Charles J BechertRanjana Nawgiri
Nov 15, 2013·The Journal of Investigative Dermatology·Seri N E SarchioScott N Byrne
Aug 13, 2008·Journal of the American Academy of Dermatology·Warren R Heymann
Aug 2, 2008·Allergy·E Jensen-JarolimH Gould
Apr 30, 2013·International Journal of Dermatology·Asok BiswasMeera Mahalingam
Aug 31, 2012·Oncoimmunology·David Z Chang
Dec 12, 2017·F1000Research·Gerhard J MolderingsLawrence B Afrin
Feb 19, 2009·Molecular Human Reproduction·M G Katz-JaffeW B Schoolcraft
Apr 27, 2010·Advances in Anatomic Pathology·Kenneth B Calder, Bruce R Smoller
Dec 12, 2012·Scientific Reports·Mitsutoshi YamadaMasaru Tomita
May 1, 2019·International Journal of Molecular Sciences·Giuseppe SammarcoRiccardo Memeo
Jun 25, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mika Yamanaka-TakaichiDaisuke Tsuruta
Apr 28, 2009·Advances in Anatomic Pathology·Melissa P PulitzerKlaus J Busam
Aug 10, 2017·Frontiers in Medicine·Maria Rosaria GaldieroGianni Marone
Oct 25, 2016·Experimental Dermatology·Gilda VarricchiGianni Marone
Jun 9, 2020·Frontiers in Immunology·Tao ChenZhaoming Ye
Feb 13, 2018·Immunological Reviews·Gilda VarricchiBernhard F Gibbs
Apr 28, 2017·Frontiers in Immunology·Gilda VarricchiFrancescopaolo Granata
Nov 1, 2020·Journal of Cutaneous Pathology·Noreen M Walsh, Lorenzo Cerroni
Apr 30, 2014·Cancer Immunology Research·Thomas MarichalStephen J Galli
Jan 11, 2013·Molecular Cancer Therapeutics·Thiruvengadam ArumugamCraig D Logsdon
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David Z ChangPatrick Hwu
Jul 25, 2021·Cancers·Clara BertuzziClaudio Agostinelli
Sep 28, 2021·International Journal of Dermatology·Daniel Elieh Ali Komi, Ahmad Jalili
May 29, 2019·International Archives of Allergy and Immunology·Gilda VarricchiGianni Marone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.