PMID: 9529682Apr 8, 1998Paper

Mast cells in clinical dermatology

The Australasian Journal of Dermatology
Y Miyachi, M Kurosawa

Abstract

Recent advances in cutaneous mast cell biology are briefly reviewed with special reference to our own studies on cultured human mast cells. Of note are the heterogeneity of mastocytosis, the important participation of mast cells in allergic inflammation by releasing cytokines and the inhibitory effect of histamine release from mast cells by phototherapy. It is also stressed that mast cells play a major role in tissue remodelling. These novel findings suggest that mast cells can no longer be regarded simply as cells that initiate immediate allergic reactions, but that they are responsible for various chronic inflammatory or immunological events through cytokine-dependent leucocyte recruitment. The regulation of mast cell activation should be a critical issue and, thus, a promising therapeutic approach in clinical dermatology.

References

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Citations

Jun 5, 2002·Current Allergy and Asthma Reports·Naotomo KambeYoshiki Miyachi
Feb 12, 2002·The Journal of Dermatology·Naotomo Kambe, Yoshiki Miyachi
Feb 6, 2004·Dermatologic Therapy·Patricia T Ting, Marlene T Dytoc
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B RoyerM Arock
Mar 10, 2001·The Australasian Journal of Dermatology·R Hannaford, M Rogers
Jul 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R SnoeckE De Clercq
Jun 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sadie E F JonesAmanda J Tristram
Dec 2, 2004·Dermatologic Therapy·Allison Rivera, Stephen K Tyring

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