PMID: 2099356Jan 1, 1990Paper

Mast cells in the ovine lower respiratory tract: heterogeneity, morphology and density

International Archives of Allergy and Applied Immunology
W ChenP Davey

Abstract

The lower respiratory tract (LRT) of 6 adult sheep was fixed in either isotonic formalin-acetic acid or neutral buffered formalin in order to study the heterogeneity, morphology and density of mast cells (MCs). Two subtypes of MCs were found, one histochemically similar to connective tissue MCs (formalin resistant) and the other similar to mucosal MCs as found in the intestine of the rat (formalin sensitive). Although both subtypes were present at all levels of the tract, formalin-sensitive MCs were significantly more abundant (p less than 0.01) at all levels, and their density increased distally from the trachea to the peripheral lung. The formalin-sensitive MCs were predominantly located in the alveolar septa and in the superficial lamina propria of airways and less frequently within the airway epithelium. The MCs in the ovine LRT were found to be morphologically heterogeneous at both the light-microscopic and electron-microscopic levels. These findings indicate that ovine respiratory tract MCs have similarity to human lung MCs, and therefore potential for use as a model for the study of human allergic disease of the respiratory system.

Citations

Mar 21, 2008·Trends in Biotechnology·Jean-Pierre Y ScheerlinckPhilip Sutton
Nov 1, 1992·Journal of Comparative Pathology·J F Huntley
Oct 25, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K J DacreA D Pemberton
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D D S Collie
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J BischofE N T Meeusen

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