PMID: 11920701Mar 29, 2002Paper

Mast cells in Wallerian degeneration: morphologic and ultrastructural changes

The Journal of Comparative Neurology
Barbara EspositoGabriella Chieffi Baccari

Abstract

The morphologic and ultrastructural changes of mast cells were followed in degenerating distal and regenerating proximal stumps of frog brachial nerve during Wallerian degeneration. Quantitative analysis included determination of both number and size of mast cells. The mast cell response to injury consisted of an early and a late phase. In the early phase, there was an increase in mast cell numbers in the proximal site of the lesion and a release of Alcian blue material consistent with mediator release. This phase of mast cell activation may be related, through the secretion of biogenic agents such as heparin and histamine, to the increase of endoneurial vessel size and vascular permeability, providing access for macrophages and mast cell precursors. The later phase, which peaked at 40 days after transection in the degenerating distal stump, consisted in the degranulation of the mast cells. These mast cells, closely associated with macrophages and degenerating Schwann cells, released secretory granules into the endoneurial microenvironment. These degranulating mast cells, through the released acid hydrolases, may contribute along with macrophages and Schwann cells, to the degradation of myelin debris. At the same time, mast cel...Continue Reading

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Citations

Jan 15, 2010·Journal of Anatomy·Claudia PinelliRakesh K Rastogi
Apr 1, 2015·Anatomia, histologia, embryologia·E BiasibettiM T Capucchio
Nov 6, 2003·Microscopy Research and Technique·Gabriella Chieffi BaccariRossella Monteforte
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Feb 16, 2021·Frontiers in Aging Neuroscience·Kathleen M Hagen, Shalina S Ousman
May 4, 2010·The Journal of Experimental Biology·Rossella MonteforteGabriella Chieffi Baccari

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