Mast cells influence the proliferation rate of myeloma plasma cells

Cancer Investigation
C A PappaMichael G Alexandrakis

Abstract

In multiple myeloma (MM), mast cells (MCs) modify bone marrow microenvironment. In order to estimate whether MC density (MCD) in active MM bone marrows relates to the proliferative activity of plasma cells, we estimated in 42 patients MCD, microvascular density (MVD), and the Ki-67 proliferation index (PI) (immunohistochemical expression of tryptase, CD31, and Ki-67). MCD correlated with Ki-67 PI (p < .001), suggesting the important participation of MCs in MM biology and growth; MCs enhance angiogenesis and produce cytokines with growth effects on myeloma cells. Therefore, MCs could be valuable targets for therapeutic interventions.

References

Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·J R StarkeyS Taubenberger
Apr 1, 1989·Annals of Internal Medicine·B BarlogieR Alexanian
Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C JenkinsS Moncada
Aug 1, 1996·The European Respiratory Journal·M DrentM van Dieijen-Visser
Jun 1, 1997·The Journal of Clinical Investigation·R J BlairB L Gruber
Jul 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A GrützkauB M Henz
Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L Benítez-BribiescaE Castellanos
Jul 12, 2003·Blood·Angelo VaccaFranco Dammacco
Apr 22, 2004·Trends in Immunology·Theoharis C Theoharides, Pio Conti
Nov 3, 2004·The Journal of Clinical Investigation·Takayuki NakayamaGiovanna Tosato
Nov 17, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RibattiA Vacca
Jun 22, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O TournilhacS P Treon
Jan 22, 2008·Stem Cells and Development·Beatrice NicoDomenico Ribatti
Mar 28, 2009·Leukemia Research·Domenico RibattiStefano Molica
Apr 22, 2011·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Angelo Vacca, Domenico Ribatti
Jun 28, 2011·Advances in Cancer Research·Miguel LemaireKarin Vanderkerken
Sep 10, 2011·Clinical Lymphoma, Myeloma & Leukemia·Maria GkotzamanidouMeletios A Dimopoulos
Aug 13, 2013·BioMed Research International·Michael G AlexandrakisGeorge Tsirakis
Feb 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C A PappaM G Alexandrakis

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Citations

Oct 2, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·G ShayC C Lynch
Jan 27, 2019·International Journal of Molecular Sciences·Domenico RibattiAngelo Vacca

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