Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice

Immunity, Inflammation and Disease
Naoto YoshinoShigehiro Sato

Abstract

Surfactin (SF) is a cyclic lipopeptide that has potent mucosal adjuvant properties. However, immunological mechanisms of SF adjuvant action have not yet been elucidated. As some cyclic lipopeptides, such as polymyxin, can stimulate histamine release from mast cells, we hypothesized that mast cell activation is critical for SF adjuvanticity. We observed that following intranasal immunization with ovalbumin (OVA) plus SF, the titers of the OVA-specific antibody (Ab) in the mucosal secretions and plasma of mast cell-deficient mice were significantly lower than those in congenic normal mice, although OVA-specific Ab did not entirely disappear from mast cell-deficient mice. SF induced degranulation of mast cells and release of histamine in vitro. To investigate whether SF stimulated mast cells in vivo, we measured body temperature of mice immunized intranasally with OVA plus SF because histamine level affects body temperature. Following immunizations, body temperature of immunized congenic normal mice transiently decreased, whereas body temperature of mast cell-deficient mice did not change. Plasma levels of OVA-specific IgE Ab were not significantly different in mast cell-deficient and congenic normal mice. These findings suggest t...Continue Reading

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Citations

Jun 24, 2018·Scandinavian Journal of Immunology·Naoto YoshinoShigehiro Sato
Aug 30, 2019·Journal of Virology·Bryan A JohnsonVineet D Menachery
Dec 2, 2020·Cells·Konstantinos Katsoulis-DimitriouAnne Dudeck
May 19, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Naoto YoshinoYasushi Muraki
Jul 8, 2021·International Immunopharmacology·Hee-Yun KimHyun-Ja Jeong
Sep 28, 2021·Frontiers in Immunology·Brandi T Johnson-WeaverHerman F Staats

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