Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway

The Journal of Immunology : Official Journal of the American Association of Immunologists
Norika ChibaMoshe Arditi

Abstract

Mast cells are known as central players in allergy and anaphylaxis, and they play a pivotal role in host defense against certain pathogens. Chlamydia pneumoniae is an important human pathogen, but it is unclear what role mast cells play during C. pneumoniae infection. We infected C57BL/6 (wild-type [WT]) and mast cell-deficient mice (Kit(W-sh/W-sh) [Wsh]) with C. pneumoniae. Wsh mice showed improved survival compared with WT mice, with fewer cells in Wsh bronchoalveolar lavage fluid (BALF), despite similar levels of cytokines and chemokines. We also found a more rapid clearance of bacteria from the lungs of Wsh mice compared with WT mice. Cromolyn, a mast cell stabilizer, reduced BALF cells and bacterial burden similar to the levels seen in Wsh mice; conversely, Compound 48/80, a mast cell degranulator, increased the number of BALF cells and bacterial burden. Histology showed that WT lungs had diffuse inflammation, whereas Wsh mice had patchy accumulations of neutrophils and perivascular accumulations of lymphocytes. Infected Wsh mice had reduced amounts of matrix metalloprotease-9 in BALF and were resistant to epithelial integral membrane protein degradation, suggesting that barrier integrity remains intact in Wsh mice. Mast c...Continue Reading

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Citations

Apr 15, 2020·Infection and Immunity·Mads LausenSvend Birkelund
Jul 25, 2019·Frontiers in Microbiology·Hongliang ChenZhongyu Li
Jun 13, 2018·Frontiers in Immunology·Marcia Campillo-NavarroRommel Chacón-Salinas
May 23, 2021·Scientific Reports·Karen Magdalena Garcia-RodriguezRogelio Hernández-Pando
Dec 2, 2021·International Immunology·Visai Muruganandah, Andreas Kupz

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