Mast Cells Respond to Cell Injury through the Recognition of IL-33.

Frontiers in Immunology
Carolina Lunderius-AnderssonGunnar Nilsson

Abstract

Mast cells have been attributed several functions in both health and disease. Mast cell activation and release of inflammatory mediators are associated with the pathogenesis of several diseases, in particular that of allergic diseases. While the notion of mast cells as important, protective sentinel cells is old, this feature of the cell is not well recognized outside the mast cell field. The mast cell is a unique, multifunctional cell of our defense system, with characteristics such as wide-spread tissue distribution, expression of receptors capable of recognizing both endogenous and exogenous agents, and a capability to rapidly respond to triggering factors by selective mediator release. In this review, we discuss the function of mast cells as sentinel cells in the context of cell injury, where mast cells respond by initiating an inflammatory response. In this setting, IL-33 has turned out to be of particular interest. IL-33 is released by necrotic structural cells and is recognized by mast cells via the IL-33 receptor ST2. IL-33 and mast cells probably constitute one important link between cell injury and an inflammatory response that can lead to restoration of tissue function and homeostasis, but might under other circumsta...Continue Reading

Citations

Oct 17, 2012·PloS One·Shinjiro KaiedaPeter A Nigrovic
Nov 16, 2013·Seminars in Immunology·Michael U Martin
Apr 24, 2014·Advances in Wound Care·Carlos ZgheibKenneth W Liechty
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jun-Xia WangPeter A Nigrovic
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Rebecca L MaywaldJason D Heaney
Jan 20, 2016·Nature Immunology·Nikolas T Martin, Michael U Martin
Aug 11, 2015·European Journal of Immunology·Geethani BandaraDean D Metcalfe
Nov 7, 2012·Trends in Immunology·Laurent L ReberStephen J Galli
Jun 18, 2015·Immunity·Ari B MolofskyRichard M Locksley
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·David D LoH Peter Lorenz
Oct 1, 2014·Journal of Periodontal Research·S KöseoğluH H Esen
Jun 9, 2015·European Journal of Pharmacology·Rohit SalujaGunnar Nilsson
Jul 17, 2014·Seminars in Immunology·Judith E Allen, Tara E Sutherland
Feb 11, 2015·Immunology Letters·Jingli LuXiaojian Zhang
Aug 26, 2014·Cellular & Molecular Immunology·Marc BeckerMatthias J Reddehase
May 6, 2015·European Journal of Pharmacology·Theoharis C TheoharidesIsaac Melamed
Mar 8, 2017·International Journal of Immunogenetics·G A QueirozC A Figueiredo
Nov 27, 2018·Physiological Reviews·Melanie RodriguesGeoffrey C Gurtner
Jan 8, 2019·Journal of Biomedical Materials Research. Part a·Daniel AbebayehuJohn J Ryan
May 3, 2014·Annals of Biomedical Engineering·Michael S HuH Peter Lorenz
Oct 31, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Louise M JuddAndrew S Giraud
Jun 11, 2020·The Journal of Experimental Medicine·James W SwannThibault Griseri
Aug 26, 2020·Toxicology and Industrial Health·Sofie Van Den BrouckePeter Hoet
Apr 25, 2015·The Journal of Pharmacology and Experimental Therapeutics·Theoharis C TheoharidesPio Conti
Jan 10, 2019·Particle and Fibre Toxicology·Brian C PalmerLisa A DeLouise
Jan 30, 2020·Frontiers in Endocrinology·Leanne GrobanSarah H Lindsey
Feb 1, 2013·Experimental Dermatology·Jenny SeltmannMiriam Wittmann
Jul 14, 2017·Frontiers in Immunology·Olga KurowAxel J Hueber
Feb 13, 2018·Immunological Reviews·Ivana HalovaPetr Draber
Oct 23, 2018·Frontiers in Immunology·Avinash RavindranGunnar Nilsson
Feb 5, 2021·Advanced Drug Delivery Reviews·Emrullah KorkmazLouis D Falo
Jun 3, 2021·International Journal of Molecular Sciences·Shun Kimura, Takashi Tsuji
Aug 24, 2021·American Journal of Physiology. Renal Physiology·Goutham PattabiramanPraveen Thumbikat

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Mattias EnokssonCarolina Lunderius-Andersson
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Matthew R SilverDivya Chaudhary
© 2021 Meta ULC. All rights reserved