Master mechanisms of Staphylococcus aureus: consider its excellent protective mechanisms hindering vaccine development!

Microbiological Research
Xu ZhangHua-Li Qin

Abstract

Lack of known mechanisms of protection against Staphylococcus aureus in humans represents an important risk factor for skin infections and bacteremia in patients, intern hindering the development of efficacious vaccines. However, development of effective humoral response may be dampened by converging immune-evasion mechanisms of S. aureus. To develop a promising vaccine against S. aureus, it is pre-requisite to clear understanding of cutaneous, innate and adaptive immune response. The S. aureus dampening the humoral response, T cell help, blocking complement factors, and killing immune players by its toxins are the important factors need to understand clearly. We hypothesized that the master mechanism of S. aureus counteracts may hindering the immune action which may result in failure of target-oriented vaccine development. Developing immunological interventions that can effectively block the S. aureus counteracting mechanisms are the key success for a developing vaccine for the future was warranted.

Citations

Jul 14, 2020·Indian Journal of Microbiology·Shikhar SharmaDeepak Gaur
Jan 4, 2021·European Journal of Medicinal Chemistry·Sumit KumarVipan Kumar
Aug 3, 2019·Bioorganic Chemistry·Man XuK P Rakesh
Oct 10, 2020·European Journal of Medicinal Chemistry·Barbara ParrinoPatrizia Diana
Nov 2, 2019·European Journal of Medicinal Chemistry·Hao LiuGao-Feng Zha

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