Masticatory muscles of mouse do not undergo atrophy in space

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Anastassios PhilippouElisabeth R Barton

Abstract

Muscle loading is important for maintaining muscle mass; when load is removed, atrophy is inevitable. However, in clinical situations such as critical care myopathy, masticatory muscles do not lose mass. Thus, their properties may be harnessed to preserve mass. We compared masticatory and appendicular muscles responses to microgravity, using mice aboard the space shuttle Space Transportation System-135. Age- and sex-matched controls remained on the ground. After 13 days of space flight, 1 masseter (MA) and tibialis anterior (TA) were frozen rapidly for biochemical and functional measurements, and the contralateral MA was processed for morphologic measurements. Flight TA muscles exhibited 20 ± 3% decreased muscle mass, 2-fold decreased phosphorylated (P)-Akt, and 4- to 12-fold increased atrogene expression. In contrast, MAs had no significant change in mass but a 3-fold increase in P-focal adhesion kinase, 1.5-fold increase in P-Akt, and 50-90% lower atrogene expression compared with limb muscles, which were unaltered in microgravity. Myofibril force measurements revealed that microgravity caused a 3-fold decrease in specific force and maximal shortening velocity in TA muscles. It is surprising that myofibril-specific force from...Continue Reading

References

Aug 1, 1992·Journal of Applied Physiology·Y OhiraV R Edgerton
Dec 1, 1990·Canadian Journal of Physiology and Pharmacology·A BouronG Raymond
Dec 19, 1996·The New England Journal of Medicine·W E Mitch, A L Goldberg
Aug 1, 1997·The American Journal of Physiology·D L AllenV R Edgerton
Jan 27, 1998·The Journal of Biological Chemistry·T YoshidaM Shigekawa
Nov 26, 1999·Acta Physiologica Scandinavica·J MäntyvaaraA Pertovaara
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R H FittsJ J Widrick
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D GomesA L Goldberg
Dec 18, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James A CarsonJames M Reecy
Dec 20, 2002·Connective Tissue Research·Hidemitsu HaradaHideyo Ohuchi
Jan 18, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·Y OhiraV R Edgerton
Jul 29, 2003·Journal of Applied Physiology·B C HarrisonL A Leinwand
Aug 28, 2003·Experimental Cell Research·Liming YuPaulette J McCormick
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ashok KumarAladin M Boriek
Oct 8, 2004·American Journal of Physiology. Cell Physiology·D A RileyR H Fitts
Oct 14, 2004·Physiological Genomics·Christoph DäppMartin Flück
May 13, 2005·American Journal of Physiology. Cell Physiology·Dustin D Armstrong, Karyn A Esser
Sep 16, 2005·American Journal of Physiology. Cell Physiology·Elisabeth R Barton
Oct 18, 2005·Muscle & Nerve·Susan C Kandarian, Robert W Jackman
Aug 31, 2006·Acta Anaesthesiologica Scandinavica·H NormanL Larsson
Nov 22, 2007·Archives of Oral Biology·David W DanielsElisabeth R Barton
Dec 17, 2008·Journal of Applied Physiology·David L AllenJeremy L Barth
Jan 20, 2009·Journal of Applied Physiology·Scott TrappeRobert H Fitts
Jun 2, 2009·European Journal of Applied Physiology·Mark D SchuenkeL Perry Koziris
Sep 18, 2009·American Journal of Physiology. Cell Physiology·Michael R MorissetteAnthony Rosenzweig
Dec 29, 2009·Biochemical and Biophysical Research Communications·Margaret E Benny KlimekTeresa A Zimmers
Jan 29, 2011·Journal of Applied Physiology·Kate T MurphyGordon S Lynch
Apr 4, 2012·PloS One·Dorianna SandonàStefano Schiaffino
Feb 8, 2014·Disease Models & Mechanisms·Elizabeth M MacDonaldRonald D Cohn
Jan 1, 2014·Skeletal Muscle·Lucas R Smith, Elisabeth R Barton

❮ Previous
Next ❯

Citations

Feb 26, 2016·PloS One·Loïc TreffelCatherine Millet
Dec 17, 2019·Acta Physiologica·Rizwan QaisarAdel B Elmoselhi
Sep 26, 2015·American Journal of Physiology. Cell Physiology·Anabelle S CornachioneDilson E Rassier
Apr 30, 2020·International Journal of Molecular Sciences·Xiao LinAirong Qian
Mar 19, 2021·Frontiers in Endocrinology·Sonja BuvinicViviana Toro-Ibacache
May 1, 2021·International Journal of Molecular Sciences·Athanasios MoustogiannisMichael Koutsilieris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.