Mastomys Species as Model Systems for Infectious Diseases

Viruses
Daniel Hasche, Frank Rösl

Abstract

Replacements of animal models by advanced in vitro systems in biomedical research, despite exceptions, are currently still not satisfactory in reproducing the whole complexity of pathophysiological mechanisms that finally lead to disease. Therefore, preclinical models are additionally required to reflect analogous in vivo situations as found in humans. Despite proven limitations of both approaches, only a combined experimental arrangement guarantees generalizability of results and their transfer to the clinics. Although the laboratory mouse still stands as a paradigm for many scientific discoveries and breakthroughs, it is mandatory to broaden our view by also using nontraditional animal models. The present review will first reflect the value of experimental systems in life science and subsequently describes the preclinical rodent model Mastomys coucha that-although still not well known in the scientific community-has a long history in research of parasites, bacteria, papillomaviruses and cancer. Using Mastomys, we could recently show for the first time that cutaneous papillomaviruses-in conjunction with UV as an environmental risk factor-induce squamous cell carcinomas of the skin via a "hit-and-run" mechanism. Moreover, Masto...Continue Reading

References

Jun 1, 1975·Journal of Immunological Methods·B K Shenton, E J Field
Dec 31, 1975·Archives of Dermatological Research·R Rudolph, M Hundeiker
Nov 1, 1991·The Journal of General Virology·M SiegsmundE Amtmann
Jan 1, 1991·Acta Oncologica·I M ModlinJ R Goldenring
Jun 1, 1991·Infection and Immunity·L ArntzenM Isaäcson
Jul 1, 1970·The American Journal of Tropical Medicine and Hygiene·J D FrameJ M Troup
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·J J Harvey
Apr 1, 1973·Die Naturwissenschaften·H BurtscherG Meingassner
Jan 1, 1968·Transactions of the Royal Society of Tropical Medicine and Hygiene·D H DavisK F Meyer
May 15, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T F MassoudF Viñuela
Dec 30, 1999·Nature Genetics·J A BeckE M Fisher
Jun 7, 2003·Journal of Clinical Microbiology·Annika AntonssonBengt Göran Hansson
Feb 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·S S SCHNEIERSON, E PERLMAN
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Oct 1, 2005·Nature Reviews. Cancer·Vladimir N AnisimovAnatoly I Yashin
Feb 4, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddM C Champaneria
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddS M Mane
Mar 1, 2007·Emerging Infectious Diseases·Emilie LecompteJan ter Meulen
Oct 30, 2007·Journal of Medical Microbiology·Timothy J J Inglis
Jan 18, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristin AnderssonJoakim Dillner
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Jan 19, 2008·Journal of Molecular Neuroscience : MN·Mariz VainzofLydia U Yamamoto
Apr 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Anthony DelaneyUNKNOWN Protocolised Management In Sepsis (ProMISe) Investigators
Jul 9, 2008·Disability and Rehabilitation·Spencer P LakeLouis J Soslowsky
Aug 29, 2009·Nature Protocols·Erika L AbelJohn DiGiovanni
Oct 6, 2009·Journal of Virological Methods·Kai SchäferFrank Rösl
May 27, 2010·British Journal of Cancer·P WorkmanUNKNOWN Committee of the National Cancer Research Institute

❮ Previous
Next ❯

Citations

Feb 14, 2020·Journal of Virology·Megan E Spurgeon, Paul F Lambert

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
RNAseq
hysterectomy

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.