Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins

Biochemical and Biophysical Research Communications
Y OzakiS Kume

Abstract

Mastoparan induced limited release of serotonin from intact human platelets, while neither intracellular calcium ion elevation nor arachidonic acid mobilization was observed. Cytolysis induced by mastoparan was negligible in the concentration range that induced serotonin release. In digitonin-permeabilized cells, mastoparan induced Ca(++)-independent release of serotonin and Ca(++)-dependent arachidonic acid release. Both serotonin release and arachidonic acid release were reduced by pertussis toxin, suggesting that platelet activation induced by mastoparan is mediated by GTP-binding proteins.

References

Aug 1, 1979·Chemical & Pharmaceutical Bulletin·Y HiraiC Kitada
Feb 15, 1989·Biochemical and Biophysical Research Communications·N YokokawaT Yamada

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Citations

Dec 1, 1996·Journal of Cellular Physiology·T MurayamaY Nomura
Dec 14, 2001·Biochemical and Biophysical Research Communications·M Ohara-ImaizumiS Nagamatsu
Dec 12, 1991·Biochimica Et Biophysica Acta·M Lindau, B D Gomperts
Jan 22, 2003·Biochemical and Biophysical Research Communications·Juana López-GodínezJesús García-Soto
Sep 29, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B D FordJ G Townsel
May 5, 1998·Fundamental & Clinical Pharmacology·A ChahdiY Landry
Jun 1, 1995·British Journal of Pharmacology·B W McFerran, S B Guild
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Motohiko SatoStephen M Lanier
Jan 5, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Satoko Ohkubo, Norimichi Nakahata
Sep 15, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Norimichi Nakahata, Jun Sugama
Feb 18, 2016·Neural Plasticity·Valerie T RamírezNibaldo C Inestrosa
Nov 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Hailong YangRen Lai
Dec 31, 2014·Parasitology Research·Nora L El-Tantawy
Aug 19, 2007·Biochemical and Biophysical Research Communications·Hidehito MukaiEisuke Munekata
Dec 20, 1996·The Journal of Biological Chemistry·B C SuhK T Kim
Mar 3, 1995·The Journal of Biological Chemistry·D R PfeifferW L Erdahl
Dec 1, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Aljosa Bavec
May 13, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea S RothmeierWolfram Ruf
May 5, 2021·Antioxidants & Redox Signaling·Renato Simões Gaspar, Jonathan M Gibbins
Jan 26, 2010·Toxicon : Official Journal of the International Society on Toxinology·Thalita RochaMaria Alice da Cruz-Höfling

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