Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia

Neurochemical Research
Peng XuYi-Zhun Zhu

Abstract

Chronic neuroinflammation is a pathological feature of neurodegenerative diseases. Inhibition of microglia-mediated neuroinflammation might be a potential strategy for neurodegeneration. Matairesinol, a dibenzylbutyrolactone plant lignan, presents in a wide variety of foodstuffs. It has been found to possess anti-angiogenic, anti-oxidative, anti-cancer and anti-fungal activities. In the present study, we investigated the anti-neuroinflammation effects of matairesinol on lipopolysaccharide (LPS)-induced BV2 microglia cells and the related molecular mechanisms. The results showed that matairesinol inhibited microglia activation by reducing the production of nitric oxide, the expression of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner (6.25, 12.5, 25 μM). In the molecular signaling pathway, LPS-induced nuclear factor-kappa B (NF-κB) transcriptional activity and translocation into the nucleus were remarkably suppressed by matairesinol through the inhibition of the extracellular signal-regulated kinase (ERK)1/2 signal transduction pathways, but not p38 MAPK or c-jun N-terminal kinase (JNK). Meanwhile, matairesinol also blocked LPS-mediated microglia migration and this was associated with in...Continue Reading

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Citations

Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin-Mu YiOk-Sun Bang
Jul 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lisa I Pilkington
Nov 22, 2019·Current Computer-aided Drug Design·Rahitha Devi S J, Prakash Kumar B
Oct 28, 2020·Canadian Journal of Physiology and Pharmacology·Yanjun ZhaoHongbing Wang
Apr 17, 2018·Journal of Agricultural and Food Chemistry·Satoshi YamauchiHisashi Nishiwaki
Dec 10, 2019·Journal of Proteome Research·Moab T AndradeFrancisco A P Campos
Sep 17, 2021·Molecular Neurobiology·Barbara BettegazziDaniele Zacchetti
Feb 1, 2020·Current Medicinal Chemistry·Amir R AfshariAmirhossein Sahebkar

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Methods Mentioned

BETA
protein assay
nuclear translocation

Software Mentioned

GraphPad
Prism
AxioVision
Alpha Imager

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