Matched-cohort analysis of patients with prostate cancer followed with observation or treated with three-dimensional conformal radiation therapy

BJU International
Noel M KramerGerald E Hanks

Abstract

To compare the outcome of similar patients with prostate cancer treated by either observation or three-dimensional conformal radiation therapy (3-DCRT). The study included 69 patients with nonmetastatic prostate cancer who were observed only; the indications included indolent disease, significant medical comorbidities and refusal of treatment. Of these, 62 patients had palpable T1-T2a and seven T2b-T3a disease, a median Gleason score of 6 and a median initial prostate-specific antigen (PSA) level of 5.3 ng/mL. A matched-cohort analysis of 69 patients, based on palpation T category, Gleason score and initial PSA, was used to compare the outcome between the observation and 3-DCRT groups. The median radiation dose for latter was 72 Gy. The median follow-up for the observed patients was 49 months. The 5- and 8-year actuarial rates of freedom from distant metastases were 100% and 93%, respectively, and the actuarial overall survival rates 94% and 73%, respectively. Seven observed patients had local disease progression on physical examination. Four patients who initially were observed received radiation therapy later for a rising PSA and/or local disease progression. For the 69 matched 3-DCRT patients, the overall 5-year rate for no ...Continue Reading

References

Aug 23, 1995·JAMA : the Journal of the American Medical Association·P C AlbertsenJ Fine
Nov 1, 1994·The Journal of Urology·J E Johansson
May 11, 1999·JAMA : the Journal of the American Medical Association·W U ShipleyC D Smith
May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·P J ChubaG Hanks
Sep 13, 2002·The New England Journal of Medicine·Lars HolmbergUNKNOWN Scandinavian Prostatic Cancer Group Study Number 4

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