Matched Comparison of Microcirculation Between Healthy Volunteers and Patients with Sepsis

Asian Journal of Anesthesiology
Chung-Chih ShihYu Chang Yeh

Abstract

Sepsis-related systemic inflammation resulted in microcirculatory dysfunction. However, information of normal ranges of microcirculatory parameters in the healthy population remain limited. The primary aim of this study was to investigate the differences in microcirculatory parameters between healthy volunteers and patients with sepsis. This observational study enrolled 45 healthy female and 45 healthy male volunteers, and divided them equally into three age groups: young (20-39 years), middle-age (40-59 years), and elderly (60-79 years). In addition, we enrolled 32 patients with sepsis. Images of sublingual microcirculation were obtained through sidestream dark field videomicroscopy and were analyzed using automated analysis software. Microcirculation parameters, namely the total small vessel density (TSVD), perfused small vessel density (PSVD), proportion of perfused vessel (PPV), microvascular flow index (MFI) score, and heterogeneity index (HI), were evaluated. One-to-one matching between the septic patients and the healthy volunteers was performed on the basis of demographic data including age and gender. The elderly group had lower MFI scores and a higher HI. Age was positively correlated with the HI (r = 0.38, p < 0.001)...Continue Reading

Citations

Jun 1, 2021·Frontiers in Veterinary Science·Edward S Cooper, Deborah C Silverstein

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