Matched pilot study examining cannabis-based dronabinol for acute pain following traumatic injury

Trauma Surgery & Acute Care Open
Elisabeth Schneider-SmithDavid Bar-Or

Abstract

To determine whether adjunctive dronabinol, a licensed form of delta-9-tetrahydrocannabinol, reduces opioid consumption when used off-label for managing acute pain following traumatic injury. This matched cohort study included patients who were admitted with a traumatic injury between 1 March 2017 and 30 October 2017. The hospital pharmacy database was used to identify patients who received dronabinol (cases), and they were matched 1:1 to patients who did not receive dronabinol (controls) using age, cause of injury and hospital length of stay. The primary outcome, change in opioid consumption, was calculated using morphine milligram equivalents (MME). The change in MME was calculated for cases as total MME over 48 hours with adjunctive dronabinol minus 48 hours prior to dronabinol, and for controls as total MME 48-96 hours from admission minus 0-48 hours from admission. Data are presented as mean and SE or median and IQR. Statistical analysis was performed using paired t-tests and McNemar's tests. There were 66 patients included: 33 cases and 33 matched controls. Dronabinol was initiated 55 (28-107) hours from admission. Cases and controls were well matched. Cases had a significant reduction in opioid consumption with adjunctiv...Continue Reading

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Citations

May 31, 2020·Regional Anesthesia and Pain Medicine·Hance ClarkeLakshmi P Kotra
Nov 20, 2020·Regional Anesthesia and Pain Medicine·Jenna McAfeeErin E Bonar
Oct 24, 2020·Current Opinion in Anaesthesiology·Elyad M DavidsonAharon M Eyal
Jun 17, 2021·JAMA Surgery·Camille Stewart, Yuman Fong
Jun 17, 2021·JAMA Surgery·Elyad M DavidsonAharon M Eyal

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Methods Mentioned

BETA
hysterectomies

Clinical Trials Mentioned

NCT03928015

Software Mentioned

SAS

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