Matched population-based study examining the risk of type 2 diabetes in people with and without diagnosed hepatitis C virus infection

Journal of Viral Hepatitis
C SchnierS J Hutchinson

Abstract

Meta-analyses have found hepatitis C virus (HCV) infection to be associated with an increased risk of type 2 diabetes mellitus (T2DM). Here, we examine this association within a large population-based study, according to HCV RNA status. A data-linkage approach was used to examine the excess risk of diagnosed T2DM in people diagnosed with antibodies to HCV (anti-HCV) in Scotland (21 929 anti-HCV(+ves) ; involving 15 827 HCV RNA(+ves) , 3927 HCV RNA(-ves) and 2175 with unknown RNA-status) compared to that of a threefold larger general population sample matched for gender, age and postcode (65 074 anti-HCV(-ves) ). To investigate effects of ascertainment bias the following periods were studied: up to 1 year before (pre-HCV)/within 1 year of (peri-HCV)/more than 1 year post (post-HCV) the date of HCV-diagnosis. T2DM had been diagnosed in 2.9% of anti-HCV(+ves) (including 3.2% of HCV RNA(+ves) and 2.3% of HCV RNA(-ves) ) and 2.7% of anti-HCV(-ves) . A higher proportion of T2DM was diagnosed in the peri-HCV period (i.e. around the time of HCV-diagnosis) for the anti-HCV(+ves) (22%) compared to anti-HCV(-ves) (10%). In both the pre-HCV and post-HCV periods, only those anti-HCV(+ves) living in less deprived areas (13% of the cohort) we...Continue Reading

References

Jan 1, 1990·American Journal of Epidemiology·S Greenland, H Morgenstern
Sep 7, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·J M EvansA D Morris
Dec 29, 2000·Diabetes Care·P T DonnanUNKNOWN Diabetes Audit and Research in Tayside, Scotland/Medicine Monitoring Unit Collaboration
Jun 25, 2002·Journal of Epidemiology and Community Health·S G WannametheeK G M M Alberti
May 14, 2003·Journal of Gastroenterology·Motohiro AraoShinichi Kakumu
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shruti H MehtaDavid L Thomas
Sep 26, 2008·Journal of Hepatology·Donna L WhiteHashem B El-Serag
Feb 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Lawrence Serfaty, Jacqueline Capeau
Apr 25, 2012·World Journal of Gastroenterology : WJG·Cho NaingMala Maung
Sep 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuji AraseTetsuro Kobayashi
Apr 10, 2013·The American Journal of Gastroenterology·L MontenegroA Di Leo
Jun 26, 2013·The American Journal on Addictions·Ayman FareedLawrence Phillips
Jul 3, 2013·Journal of Gastroenterology and Hepatology·Chia-Yen DaiHung-Da Tung
Feb 7, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Constance E RuhlJames E Everhart
Feb 20, 2014·BMC Public Health·Sun Jung KimEun-Cheol Park
Feb 26, 2014·World Journal of Diabetes·Sandip K Bose, Ranjit Ray

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Citations

Jan 13, 2018·Reviews in Endocrine & Metabolic Disorders·Silvia FabianiAlessandro Antonelli
Oct 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Yi ShenFeng Liang
Dec 28, 2018·Alimentary Pharmacology & Therapeutics·A ProvoostF Bani-Sadr

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