Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia: 10 year's experience

Bone Marrow Transplantation
M AyasH El-Solh

Abstract

Allogeneic SCT is curative for bone marrow failure in Fanconi anemia (FA) patients but the optimal conditioning regimen is undetermined. We report here our experience with 56 FA patients who underwent allogeneic matched related SCT. The conditioning regimen varied according to time of SCT and disease status at SCT; 22 patients (group A) received Cy 20 mg/kg, thoraco-abdominal radiation and antithymocyte globulins (ATG); and 34 patients (group B) received Cy 60 mg/kg and ATG. Median time to engraftment was similar (14 days) in both groups. Hemorrhagic cystitis was significantly more common in group B. Overall survival and event-free survival of all patients were 85 and 78.3% respectively. For groups A and B respectively, overall survival was 72.5 and 96.9% (P=0.013); and event-free survival was 72.5 and 82.3% (P=0.3). The use of the nonradiation Cy/ATG regimen in matched related SCT for FA patients offers better overall and event-free survival.

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Citations

Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kasiani C Myers, Stella M Davies
Mar 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Syed O A AhmedMahmoud Aljurf
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Jul 2, 2019·Journal of Pediatric Hematology/oncology·Charikleia KelaidiSophia Polychronopoulou
Jun 19, 2015·Journal of Pediatric Hematology/oncology·Alexandra Schifferli, Thomas Kühne

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