Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis

Journal of Comparative Effectiveness Research
Vibeke StrandErnest H Choy

Abstract

Aim: To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison. Patients & methods: Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weights determined by logistic regression, and used to recalculate American College of Rheumatology (ACR) responses for secukinumab, for comparison with infliximab. Results: There were no differences in outcomes between secukinumab and infliximab at weeks 6/8 and 14/16. At weeks 24 and 54/52, ACR 20 responses were higher with secukinumab 150 mg than infliximab. At week 54/52, ACR 20/50 responses were higher for secukinumab 300 mg than infliximab. Conclusion: In the mid to long term, patients receiving secukinumab were more likely to achieve ACR 20/50 responses than those receiving infliximab.

References

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Citations

Jan 24, 2019·Arthritis Research & Therapy·Ernest ChoyChiara Perella
Sep 10, 2020·Biologics : Targets & Therapy·Maria Sole ChimentiRoberto Perricone
Aug 27, 2019·Frontiers in Pharmacology·Lazaros I SakkasDimitrios P Bogdanos
Apr 23, 2020·Expert Review of Clinical Pharmacology·Francesco BellinatoGiampiero Girolomoni
Jan 31, 2021·Arthritis Research & Therapy·Amir HaddadDevy Zisman
Mar 5, 2021·Drugs·Hannah A Blair

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Clinical Trials Mentioned

NCT01752634
NCT00051623
NCT01989468

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GRAPPA
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