Matching coronary blood flow to myocardial oxygen consumption

Journal of Applied Physiology
Johnathan D TuneE O Feigl

Abstract

At rest the myocardium extracts approximately 75% of the oxygen delivered by coronary blood flow. Thus there is little extraction reserve when myocardial oxygen consumption is augmented severalfold during exercise. There are local metabolic feedback and sympathetic feedforward control mechanisms that match coronary blood flow to myocardial oxygen consumption. Despite intensive research the local feedback control mechanism remains unknown. Physiological local metabolic control is not due to adenosine, ATP-dependent K(+) channels, nitric oxide, prostaglandins, or inhibition of endothelin. Adenosine and ATP-dependent K(+) channels are involved in pathophysiological ischemic or hypoxic coronary dilation and myocardial protection during ischemia. Sympathetic beta-adrenoceptor-mediated feedforward arteriolar vasodilation contributes approximately 25% of the increase in coronary blood flow during exercise. Sympathetic alpha-adrenoceptor-mediated vasoconstriction in medium and large coronary arteries during exercise helps maintain blood flow to the vulnerable subendocardium when cardiac contractility, heart rate, and myocardial oxygen consumption are high. In conclusion, several potential mediators of local metabolic control of the cor...Continue Reading

References

Jan 1, 1979·The American Journal of Physiology·W P WatkinsonR M Berne
Mar 1, 1978·Journal of Molecular and Cellular Cardiology·G J JesmokH F Hardman
Oct 1, 1978·The American Journal of Physiology·D M HarlanH V Sparks
Jun 1, 1975·The Journal of Clinical Investigation·R W AlexanderT Cooper
Mar 1, 1977·Circulation Research·T H Hintze, G Kaley
Jan 1, 1992·Journal of Vascular Research·J QuillenD Harrison
Aug 1, 1992·The American Journal of Physiology·Y ImamuraA Takeshita
Apr 1, 1992·The American Journal of Physiology·T P Broten, E O Feigl
May 1, 1992·The American Journal of Physiology·F F SamahaR S Balaban
Apr 1, 1992·Journal of Molecular and Cellular Cardiology·J B Bassingthwaighte
Jun 1, 1991·Circulation·L R PelcD C Warltier
Jan 1, 1992·The American Journal of Physiology·R ParentM Lavallée
Dec 1, 1991·The American Journal of Physiology·C G Nichols, W J Lederer
Sep 1, 1991·The American Journal of Physiology·F L Belloni, T H Hintze
Apr 1, 1991·Journal of Molecular and Cellular Cardiology·A Deussen, J Schrader
Aug 1, 1991·Journal of Molecular and Cellular Cardiology·L J HellerD E Mohrman
Jan 1, 1990·Cellular Signalling·S J Ashcroft, F M Ashcroft
Oct 1, 1990·The American Journal of Physiology·L KuoW M Chilian
Apr 1, 1990·The American Journal of Physiology·A ChuF R Cobb
Feb 1, 1989·Circulation Research·W M ChilianM L Marcus
Jan 1, 1989·Acta Physiologica Scandinavica·A EdlundA Wennmalm
Jul 1, 1989·Progress in Cardiovascular Diseases·L BelardinelliR M Berne
Jul 1, 1989·The American Journal of Physiology·R D WanglerH V Sparks
Dec 1, 1985·The American Journal of Physiology·K Kroll, E O Feigl
Jan 1, 1987·The American Journal of Physiology·J E McKenzieF J Haddy
May 1, 1988·The American Journal of Physiology·W R Law, R M Raymond

❮ Previous
Next ❯

Citations

Jul 30, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Peter E PensonKenneth J Broadley
Apr 4, 2008·Medical & Biological Engineering & Computing·Jerome Trzeciakowski, William M Chilian
Jan 19, 2010·Chinese Journal of Integrative Medicine·Feng Qin, Xi Huang
Mar 9, 2006·Current Diabetes Reports·Raffaelle Bugiardini
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sarkis B Baghdasarian, Gary V Heller
Feb 7, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sandro GelsominoRoberto Lorusso
Jun 8, 2012·The Pediatric Infectious Disease Journal·Andras BratincsakMarian A Melish
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Sep 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Xin LongMichael Sturek
Oct 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Qun GaoMichael S Wolin
Jan 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Léna BorbouseJohnathan D Tune
Jul 30, 2011·Journal of Applied Physiology·Mostafa H El BeheiryGregory M T Hare
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A MankoffJennifer M Specht
May 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer M SpechtDavid A Mankoff
Jul 26, 2005·The Journal of Clinical Investigation·Zhi HuangMark T Gladwin
Nov 3, 2007·The Journal of Clinical Investigation·Joerg HeinekeJeffery D Molkentin
Jul 4, 2008·Blood·Mark T Gladwin, Daniel B Kim-Shapiro
Jul 23, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Roy JogiyaSven Plein
Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruyoshi KumeKiyoshi Yoshida
Jan 9, 2010·Vascular Health and Risk Management·Andrew S LevyJames W E Rush
Oct 25, 2012·Current Cardiology Reviews·Lori A Walker, Peter M Buttrick
Mar 25, 2009·Experimental Biology and Medicine·Shawn B BenderM Harold Laughlin
Nov 14, 2007·American Journal of Pharmaceutical Education·Stephen T O'Rourke
Dec 18, 2013·Cardiovascular Journal of Africa·Hakan TaşolarHasan Pekdemir
Jul 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yoji NeishiMasami Goto
Dec 25, 2013·European Heart Journal·Filippo CreaCathleen Noel Bairey Merz
May 27, 2014·The Journal of Endocrinology·Elena GrossiniGiovanni Vacca
Jun 3, 2014·Reviews in Endocrine & Metabolic Disorders·Adam G GoodwillJohnathan D Tune
Jan 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Matthew CoutsosDonal S O'Leary
May 22, 2007·Antioxidants & Redox Signaling·Michael S WolinSachin A Gupte
Feb 25, 2009·Current Cardiology Reports·Henry Gewirtz
Nov 21, 2014·Nutrients·William T ClementsRichard J Bloomer
Sep 18, 2004·The Journal of Physiology·Daniel J GreenRoger Taylor
Jun 9, 2007·The Journal of Physiology·Dirk J Duncker, Daphne Merkus
Sep 6, 2008·The Journal of Physiology·Ilkka HeinonenKari K Kalliokoski
Mar 17, 2012·Journal of Molecular and Cellular Cardiology·Gerd Heusch
Nov 1, 2011·Journal of Molecular and Cellular Cardiology·Dirk J DunckerDaphne Merkus
Aug 16, 2011·Journal of Molecular and Cellular Cardiology·Tim P van de HoefMaria Siebes

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