Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

International Journal of Immunogenetics
Kirsten Geneugelijk, Eric Spierings

Abstract

The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor-recipient compatibility. The PIRCHE algorithm determines donor-recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.

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Citations

Oct 21, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Cynthia S M KramerFrans H J Claas
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Charles F ManskiMichael Gmeiner
Dec 19, 2019·Pediatric Blood & Cancer·Wiebke StengerLena Oevermann
May 8, 2020·JCI Insight·Melinda A BiernackiMarie Bleakley
Feb 2, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abdulla EhlayelIsa F Ashoor
Feb 11, 2021·International Journal of Immunogenetics·Ann-Margaret LittlePaul A Wright
Mar 16, 2021·Frontiers in Immunology·Christian UnterrainerCaner Süsal

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