Matching of motor-sensory modality in the rodent femoral nerve model shows no enhanced effect on peripheral nerve regeneration.

Experimental Neurology
David KawamuraSusan E Mackinnon

Abstract

The treatment of peripheral nerve injuries with nerve gaps largely consists of autologous nerve grafting utilizing sensory nerve donors. Underlying this clinical practice is the assumption that sensory autografts provide a suitable substrate for motoneuron regeneration, thereby facilitating motor endplate reinnervation and functional recovery. This study examined the role of nerve graft modality on axonal regeneration, comparing motor nerve regeneration through motor, sensory, and mixed nerve isografts in the Lewis rat. A total of 100 rats underwent grafting of the motor or sensory branch of the femoral nerve with histomorphometric analysis performed after 5, 6, or 7 weeks. Analysis demonstrated similar nerve regeneration in motor, sensory, and mixed nerve grafts at all three time points. These data indicate that matching of motor-sensory modality in the rat femoral nerve does not confer improved axonal regeneration through nerve isografts.

References

Sep 1, 1990·Muscle & Nerve·D G Kline
Mar 1, 1985·Plastic and Reconstructive Surgery·S E MackinnonD A Hunter
Aug 1, 1987·Experimental Neurology·T M Brushart, W A Seiler
Oct 1, 1995·Muscle & Nerve·P J EvansR Midha
May 10, 2000·Journal of Reconstructive Microsurgery·T MatsuyamaL C Ang
Feb 13, 2001·Experimental Neurology·T B LeT M Brushart
May 4, 2001·Plastic and Reconstructive Surgery·S E MackinnonE P Trulock
Dec 17, 2003·Annals of Plastic Surgery·Maria SiemionowRomed Meirer
Oct 14, 2004·Microsurgery·Michael J BrennerThalachallour Mohanakumar
Nov 9, 2004·Experimental Neurology·Chris M NicholsSusan E Mackinnon
Mar 24, 2005·Annals of Plastic Surgery·John N JensenSusan E Mackinnon
May 19, 2005·Experimental Neurology·Thomas M BrushartTessa Gordon
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard RedettThomas M Brushart
Nov 23, 2005·Experimental Neurology·Grant A Robinson, Roger D Madison
Aug 9, 2006·Journal of Reconstructive Microsurgery·Thomas H TungMarshall E Hicks
Sep 7, 2006·The Laryngoscope·Michael J BrennerSusan E Mackinnon
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A HökeT M Brushart
Feb 10, 2007·Microsurgery·Brendan M LloydGregory H Borschel
Aug 7, 2007·Journal of Neuroscience Methods·Daniel A HunterSusan E Mackinnon
Apr 3, 2008·Microsurgery·Michael J BrennerSusan E Mackinnon
Jun 14, 2008·Experimental Neurology·Arash MoradzadehSusan E Mackinnon
Jun 10, 2009·Neuroscience·R D MadisonG A Robinson
Sep 3, 2009·Journal of Neuroscience Methods·Rahul KasukurthiDaniel A Hunter

❮ Previous
Next ❯

Citations

Aug 29, 2012·Tissue Engineering. Part B, Reviews·Mark SzynkarukGregory H Borschel
Jun 13, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Callum Faris, Robin Lindsay
Sep 4, 2015·The European Journal of Neuroscience·Miyuki SakumaClifford J Woolf
Feb 15, 2015·Experimental Neurology·Matthew D Wood, Susan E Mackinnon
Nov 22, 2012·Muscle & Nerve·Grant A Robinson, Roger D Madison
Aug 13, 2013·Experimental Neurology·M AbdullahT M Brushart
Mar 14, 2012·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Peng JianpingJiang Baoguo
May 3, 2015·Hand Clinics·Matthew T Houdek, Alexander Y Shin
Feb 16, 2011·Journal of Neuroscience Methods·Ayhan KilicPeter Tang
Mar 15, 2015·Hand : Official Journal of the American Association for Hand Surgery·Louis H PopplerSusan E Mackinnon
Nov 23, 2017·Annals of Plastic Surgery·Samer Bassilios HabrePetros Konofaos
Jun 28, 2011·The Journal of Veterinary Medical Science·Hiromichi OhtsukaStephen Morris
Oct 24, 2013·Plastic and Reconstructive Surgery·Neil F SachanandaniThomas H Tung
Aug 17, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Steven G HoshalArnaud F Bewley
Jan 20, 2016·MMW Fortschritte der Medizin·A Berghaus, Marion San Nicoló
Sep 24, 2020·Cells·Sara BolívarEsther Udina
Jan 23, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Yuhui KouBaoguo Jiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.