PMID: 15333729Aug 31, 2004Paper

Maternal adaptive immunity influences the intestinal microflora of suckling mice

The Journal of Nutrition
Rosa L DiazMartín G Martín

Abstract

The microflorae in the intestine of breast-fed infants are distinct from those that typically populate the intestine of formula-fed infants. Although the acquisition of passive immunity through breast-feeding may play a critical role in influencing the pattern of bacterial colonization of the gut, the precise mechanisms underlying the differences in the commensal microflorae of breast and formula-fed children have not been established. We hypothesized that the assemblage of commensal microflorae in suckling and weaned mice may be influenced by the maternal adaptive immune system. To test this hypothesis, we analyzed the intestinal microflorae of mice reared in the presence (wild-type) or absence of an intact maternal immune system (T- and B-cell deficient). Several types of bacteria (Lactobacillus, Enterococcus, Clostridium perfringens, Bifidobacterium, and Bacteroides) were isolated and enumerated from both the small and large intestine of 10-, 18-, 25- and 40- to 60-d old mice using selective media. The densities of bacteria were significantly lower in the small intestine of weaned mice that were reared by wild-type (WT) compared with immunodeficient (ID) dams. However, the microflorae were generally more abundant in the larg...Continue Reading

References

May 1, 1990·The Journal of Pediatrics·G M Ruiz-PalaciosM S West
Jan 12, 1989·Nature·N E Simister, K E Mostov
Mar 1, 1988·The Journal of Experimental Medicine·G C BosmaM J Bosma
Oct 1, 1971·Infection and Immunity·D C SavageC P Davis
Oct 1, 1983·Scandinavian Journal of Gastroenterology·O Bergstrand, G Hellers
Jun 9, 1983·The New England Journal of Medicine·R I GlassJ Holmgren
Jan 1, 1994·Advances in Experimental Medicine and Biology·J J CebraK E Shroff
Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Sep 2, 1998·Pediatrics·M A HylanderR Dhanireddy
May 18, 1999·Seminars in Immunology·R N CahillC P Cunningham
Jan 17, 2002·The New England Journal of Medicine·R M Zinkernagel
Feb 22, 2002·European Journal of Biochemistry·Cornelia LiepkeHans-Dieter Zucht
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·G MoroG Boehm
May 25, 2002·Advances in Experimental Medicine and Biology·L A PerssonO Hernell
May 25, 2002·Advances in Experimental Medicine and Biology·Michael S CaplanTamas Jilling
May 31, 2002·Nature·Pradeep K SinghMichael J Welsh
Jun 29, 2002·Applied and Environmental Microbiology·Lea ValinskyJames Borneman
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Hannah M WexlerSydney M Finegold
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania K UrenRichard A Strugnell
May 3, 2003·Annals of the New York Academy of Sciences·Lars A HansonEsbjörn Telemo
May 21, 2003·International Journal of Medical Microbiology : IJMM·Per Brandtzaeg
Jul 10, 2003·Vaccine·Philippe Van de Perre
Jul 23, 2003·Immunology·R Randal BollingerWilliam Parker

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Citations

Mar 3, 2010·Annual Review of Immunology·David A Hill, David Artis
Nov 2, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Olivia CurnoChris J Barnard
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Courtney J RobinsonVincent B Young
Nov 28, 2007·Annual Review of Pathology·Jonathan Braun, Bo Wei
Mar 22, 2013·Mucosal Immunology·M Fukata, M Arditi

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