PMID: 6988134Mar 1, 1980Paper

Maternal administration of glucocorticoids

Clinical Obstetrics and Gynecology
J C Beck, J W Johnson

Abstract

No definite comment can be made, at this time, with respect to the safety of glucocorticoid therapy in the human fetus and newborn. Obstetricians and pediatricians need to be aware of the potential risks. Whether the fetal changes that have been reported thus far are permanent and whether they will have any postnatal functional significance are questions of major importance. Probably the greatest risk associated with antenatal steroid therapy is the potential abuse of this treatment. Longer treatment periods or higher doses of steroids will increase the risk for potentially adverse side effects. The recently stated opinion of Taeusch et al seems appropriate: "We conclude that steroids are effective in reducing risk of RDS, but safer and more efficacious approaches for the prevention of RDS should be sought" (91). Further studies are needed to determine the mechanisms of action of glucocorticoids and their risk/benefit ratios in regard to fetal and neonatal well being.

Citations

Sep 1, 1995·Trends in Endocrinology and Metabolism : TEM·C J Rosen, L R Donahue
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Maarten Boers
Feb 20, 2003·Preventive Medicine·Harris H McIlwain
May 24, 2003·Journal of Hepatology·J E Hay
Sep 12, 2000·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·D P MisraC Weisman
Jan 19, 2010·Pharmacological Reports : PR·K WedzonyM Maćkowiak
Mar 1, 1982·Clinics in Endocrinology and Metabolism·I A Hughes
Jan 13, 2004·Clinics in Perinatology·John F HuddlestonKathryn W Huddleston

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Gestational Age
Glucocorticoid Effect
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Maternal-Fetal Exchange
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Pulmonary Surfactants
Glucocorticoid Receptor
Respiratory Distress Syndrome, Newborn

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