PMID: 6988134Mar 1, 1980Paper

Maternal administration of glucocorticoids

Clinical Obstetrics and Gynecology
J C Beck, J W Johnson


No definite comment can be made, at this time, with respect to the safety of glucocorticoid therapy in the human fetus and newborn. Obstetricians and pediatricians need to be aware of the potential risks. Whether the fetal changes that have been reported thus far are permanent and whether they will have any postnatal functional significance are questions of major importance. Probably the greatest risk associated with antenatal steroid therapy is the potential abuse of this treatment. Longer treatment periods or higher doses of steroids will increase the risk for potentially adverse side effects. The recently stated opinion of Taeusch et al seems appropriate: "We conclude that steroids are effective in reducing risk of RDS, but safer and more efficacious approaches for the prevention of RDS should be sought" (91). Further studies are needed to determine the mechanisms of action of glucocorticoids and their risk/benefit ratios in regard to fetal and neonatal well being.


Sep 1, 1995·Trends in Endocrinology and Metabolism : TEM·C J Rosen, L R Donahue
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May 24, 2003·Journal of Hepatology·J E Hay
Sep 12, 2000·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·D P MisraC Weisman
Jan 19, 2010·Pharmacological Reports : PR·K WedzonyM Maćkowiak
Mar 1, 1982·Clinics in Endocrinology and Metabolism·I A Hughes
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