Maternal age and chromosomal abnormalities in human oocytes

Médecine sciences : M/S
F Pellestor

Abstract

Maternal ageing is the only etiological factor unequivocally associated with the occurrence of aneuploid conceptuses. Molecular studies of trisomies have demonstrated that the pattern of recombinaison was an important predisposing factor to meiotic nondisjunction. To complete this data, a large chromosomal study has been undertaken on 1,397 unfertilised human oocytes recovered from women participating in in vitro fertilization programmes. Conventional whole chromosome nondisjunction and premature chromatid separation were the major types of numerical abnormalities observed. A positive relationship was found between maternal age and these two types of nondisjunction, but the most significant correlation was observed with chromatid separation resulting in the presence of free chromatid in metaphase II oocyte. These data revealed that chromatid separation was an essential factor in the age-dependent occurrence of aneuploidy. This finding provided new insights into the mechanism of nondisjunction in female meiosis since disturbance in molecular chromatid cohesion by cohesins might be a causal mechanism predisposing to nondisjunction and involved in the maternal age effect.

References

Jan 1, 1995·Reproduction, Fertility, and Development·S P FlahertyC D Matthews
Sep 1, 1994·Human Molecular Genetics·R S HawleyR Rasooly
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·L O RossD Dawson
Jan 1, 1996·Human Molecular Genetics·K E KoehlerT Hassold
Jul 1, 1997·American Journal of Human Genetics·R Angell
Jan 3, 2001·Molecular Human Reproduction·N SteuerwaldC A Brenner
Jan 11, 2001·Chromosoma·J Wolstenholme, R R Angell
Apr 3, 2001·Nature Reviews. Genetics·T Hassold, P Hunt
Jul 11, 2001·Novartis Foundation Symposium·K NasmythF Uhlmann
May 25, 2002·Molecular Human Reproduction·Mireia SandalinasSantiago Munné

❮ Previous
Next ❯

Citations

Aug 15, 2012·Journal of Assisted Reproduction and Genetics·I HammoudJ Selva
Mar 5, 2016·Médecine sciences : M/S·Célia RavelPatricia Viard
Jul 16, 2008·American Journal of Medical Genetics. Part a·Sophie DahounJean-Louis Blouin
Feb 28, 2015·Aging Cell·Evelyne SaadeVasily Ogryzko
Feb 15, 2005·Prenatal Diagnosis
Feb 15, 2008·Médecine sciences : M/S·M Emilie Terret, Katja Wassmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.