Maternal age at delivery and fertility of the next generation

Paediatric and Perinatal Epidemiology
Tamara S ReynoldsAmanda E Toland

Abstract

While most known causes of infertility relate to the health of the woman and/or her partner, questions have been raised regarding the possible contributions of transgenerational or epigenetic factors. The goal of this hypothesis-generating work was to examine whether Generation 1's (G1's) age at the delivery of G2 (Generation 2) was associated with G2's fertility in later life. We conducted a retrospective cohort study of women (G2s) recruited online in 2016. A questionnaire queried G2s regarding demographics and fertility. The primary exposure was G1's age at G2's birth. Outcome measures included the following: 12-month infertility, time to pregnancy, and childlessness. The adjusted relative risk (RR) of G2 infertility and childlessness by G1 age at G2's birth was estimated through a modified Poisson regression approach. The fecundity odds ratio (FOR) for the association between G1's age at G2 birth and time to pregnancy for G2 was estimated by discrete-time survival models, with complementary log-log link. A total of 2,854 women enrolled. We found no association between G1 age at G2's birth and G2 infertility. Being born to a G1 aged 15-19 years was associated with a longer time to pregnancy for G2 (FOR 0.84, 95% confidence i...Continue Reading

References

Jun 1, 1985·Biology of Reproduction·F S Vom Saal, C L Moyer
Jun 11, 1994·Lancet·N E SkakkebaekD de Kretser
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Jun 22, 2001·Proceedings. Biological Sciences·M J Hercus, A A Hoffmann
May 1, 2002·International Journal of Epidemiology·Luc J SmitsFrans W A Van Poppel
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Jun 23, 2006·Journal of Epidemiology and Community Health·Miguel A Hernán, James M Robins
Aug 25, 2006·American Journal of Epidemiology·Hazel B NicholsPolly A Newcomb
Nov 1, 2008·BMC Medical Research Methodology·Ian Shrier, Robert W Platt
Dec 6, 2008·Epidemiology·Maureen A CooneyCourtney D Lynch
Sep 8, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Claire M de VienneMichel Dreyfus
Dec 24, 2014·Singapore Medical Journal·G KangL Y Lee
Mar 11, 2015·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Rebecca Luebbert, Amelia Perez
Mar 23, 2015·Fertility and Sterility·Kerem Wainer-KatsirMichal Linial
Apr 17, 2015·Comprehensive Physiology·Barbara T AlexanderSuttira Intapad
Jul 25, 2015·Women and Birth : Journal of the Australian College of Midwives·Mustafa KaplanogluBarıs Ata
Nov 4, 2015·Scientific Reports·C E AikenS E Ozanne
Jan 19, 2016·American Journal of Preventive Medicine·Derek S BrownJuan L Rodriguez
Jun 24, 2016·Journal of Medical Internet Research·Bekeela WatsonKimberly R Jacob Arriola
Jul 3, 2016·Reproductive Sciences·Lusine AghajanovaChristopher N Herndon
Jul 17, 2016·Reproductive Toxicology·Shuk-Mei HoCarmen J Williams
Aug 10, 2016·Reproduction, Fertility, and Development·Juan J TarínAntonio Cano
Nov 7, 2016·Journal of Assisted Reproduction and Genetics·Brent HansonJames Hotaling
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
Dec 1, 2017·Nature·Marcos Francisco PerezBen Lehner
Dec 7, 2017·Human Reproduction·O BassoD P Sandler

❮ Previous
Next ❯

Citations

Nov 12, 2020·Frontiers in Genetics·Chongyang Wu, Marc-André Sirard
Apr 17, 2021·Human Reproduction·Olga BassoLauren A Wise

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.