PMID: 9643290Jun 27, 1998Paper

Maternal age specific risk rate estimates for Down syndrome among live births in whites and other races from Ohio and metropolitan Atlanta, 1970-1989

Journal of Medical Genetics
C A HuetherJ H Priest

Abstract

Our primary objective was to estimate, by one year and five year intervals, maternal age specific risk rates for Down syndrome among whites and among other races from two different populations, metropolitan Atlanta and south west Ohio, using live birth and prenatally diagnosed cases ascertained during 1970-1989. The five year estimates were also calculated separately for each of the five four year periods during these 20 years. Additionally, we compared two different methods of estimating these risk rates by using a third population of whites, and compared two different statistical methods of smoothing the risk rates. The results indicate good agreement between the metropolitan Atlanta and south west Ohio estimates within races, but show a statistically significant difference between the two race categories. Because 86% of live births in the "other races" category in the combined population are to blacks, these data may be seen as the first estimates of maternal age specific risk rates for Down syndrome among blacks calculated by one year intervals. We found excellent agreement in the risk rate estimates among the five four year time periods, between the estimates obtained by using the two different methods of estimation, and b...Continue Reading

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Citations

Sep 26, 2002·Mutation Research·Sara FriasDora Gilda Mayén
Jul 10, 2013·BMC Gastroenterology·Karl MårildJonas F Ludvigsson
May 1, 2009·Indian Journal of Human Genetics·S K Verma, R Sodhi
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Apr 30, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gert de GraafBrian G Skotko
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Sep 16, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Csaba SiffelC J Alverson
Nov 8, 2007·Prenatal Diagnosis·Lars JarupPaul Elliott
Mar 11, 2003·Prenatal Diagnosis·J K MorrisE Alberman
Aug 29, 2018·Journal of Neonatal-perinatal Medicine·S WatanabeH Boda
Sep 21, 2021·Archives of Orthopaedic and Trauma Surgery·Nicholas M HernandezThorsten M Seyler
Nov 18, 2021·Journal of Insurance Medicine·David Morel

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