PMID: 3746778Jul 1, 1986Paper

Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR). II. Inhibition of priming by placental extracts

Journal of Reproductive Immunology
J E VoisinG A Voisin

Abstract

Gestation can induce a priming for a GVHR towards paternal strain antigens, although this priming is significantly lower than the one induced by experimental immunization. A role has been sought for placental substances in decreasing this priming through immunomodulation. BALB/c (H-2d) spleen cells do not usually induce a systemic, lethal GVHR in DBA/2 (H-2d) newborn mice except when the donors are preimmunized with DBA/2 cells. Placental extracts (as well as RPMI medium or liver extracts used as controls) were added to DBA/2 cells injected into BALB/c mice used as cell donors for GVH induction. The latter's spleen cells, harvested on day 6 after immunization, were used for systemic and local GVHR. In the systemic assay (lethal effect on DBA/2 newborn mice injected i.v. with BALB/c spleen cells) a significant protection was observed. In the local assay (popliteal lymph node assay in F1 hybrids injected with BALB/c spleen cells into the foot-pad) a highly significant inhibition of priming was detected in recipients injected with spleen cells from placental extract-treated donors. The stimulation index was even lower than that obtained with unprimed BALB/c spleen cells. The same type of local GVHR in (CBA/Ca X A/J) F1 hybrids inj...Continue Reading

References

Jan 1, 1985·Journal of Reproductive Immunology·H T DucG A Voisin
Nov 1, 1985·The Journal of Pathology·D R Morgan
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·G Chaouat, S Chaffaux
Dec 1, 1984·Cellular Immunology·P BobéG A Voisin

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Citations

Sep 12, 2000·Journal of Hematotherapy & Stem Cell Research·T AboussaouiraH Gérard
Dec 2, 1999·American Journal of Reproductive Immunology : AJRI·R RaghupathyF Azizieh
Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·G A Voisin
Jul 14, 2010·International Immunopharmacology·Youn Son KimKoji Tamada
Jun 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·R G Lea, D A Clark
Apr 15, 2000·The Journal of Experimental Zoology·M R Barber, R A Fayrer-Hosken
Dec 1, 1988·Scandinavian Journal of Immunology·P BobéR Kinsky

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