Maternal ancestry and population history from whole mitochondrial genomes

Investigative Genetics
Toomas Kivisild

Abstract

MtDNA has been a widely used tool in human evolutionary and population genetic studies over the past three decades. Its maternal inheritance and lack of recombination have offered the opportunity to explore genealogical relationships among individuals and to study the frequency differences of matrilineal clades among human populations at continental and regional scales. The whole mtDNA genome sequencing delivers molecular resolution that is sufficient to distinguish patterns that have arisen over thousands of years. However, mutation rate is highly variable among the functional and non-coding domains of mtDNA which makes it challenging to obtain accurate split dates of the mitochondrial clades. Due to the shallow coalescent time of mitochondrial TMRCA at approximately 100 to 200 thousand years (ky), mtDNA data have only limited power to inform us about the more distant past and the early stages of human evolutionary history. The variation shared by mitochondrial genomes of individuals drawn from different continents outside Africa has been used to illuminate the details of the colonization process of the Old World, whereas regional patterns of variation have been at the focus of studies addressing questions of a more recent tim...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W M BrownA C Wilson
Mar 1, 1976·Developmental Biology·L Pikó, L Matsumoto
Dec 1, 1991·Journal of Molecular Evolution·D A MerriwetherD C Wallace
Sep 27, 1991·Science·L VigilantA C Wilson
Jan 1, 1987·Nature·R L CannA C Wilson
May 3, 1987·Nature·N Saitou, K Omoto
Oct 11, 1974·Nature·C A HutchisonM H Edgell
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M DenaroD C Wallace
Nov 1, 1982·Developmental Biology·G S MichaelsP J Laipis
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HoraiN Takahata
Feb 1, 1995·Brain Research. Molecular Brain Research·S IkebeT Ozawa
Apr 11, 2000·American Journal of Human Genetics·S SigurğardóttirP Donnelly
Oct 18, 2000·American Journal of Human Genetics·M RichardsH J Bandelt
Dec 29, 2000·Nature·M IngmanU Gyllensten
Sep 13, 2001·BMC Genetics·N Maca-MeyerV M Cabrera
Dec 19, 2002·American Journal of Human Genetics·M Thomas P GilbertAlan Cooper
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dan MishmarDouglas C Wallace
Feb 18, 2005·Nature·Ian McDougallJohn G Fleagle
Sep 21, 2005·Genetics·Toomas KivisildPeter J Oefner
Mar 25, 2006·Science·Michael LynchSarah Schaack
May 20, 2006·Science·C G KurlandD Penny
Dec 21, 2006·Nucleic Acids Research·Eduardo Ruiz-PesiniDouglas C Wallace
Dec 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gyaneshwer ChaubeyRichard Villems
Sep 6, 2007·PloS One·Erika TammRipan S Malhi
Dec 14, 2007·Annual Review of Genetics·Peter A Underhill, Toomas Kivisild
Apr 29, 2008·American Journal of Human Genetics·Doron M BeharUNKNOWN Genographic Consortium
May 31, 2008·Science·M Thomas P GilbertEske Willerslev
Jul 9, 2008·American Journal of Human Genetics·Simon Y W Ho, Phillip Endicott
Aug 22, 2008·PLoS Biology·Cathy Haag-LiautardPeter D Keightley
Oct 15, 2008·Human Mutation·Mannis van Oven, Manfred Kayser
Jan 13, 2009·Current Biology : CB·Ugo A PeregoAntonio Torroni
Mar 28, 2009·Proceedings. Biological Sciences·Fiona M JordanRuth Mace
Jun 9, 2009·American Journal of Human Genetics·Pedro SoaresMartin B Richards
Dec 31, 2009·PloS One·Eva-Liis LoogväliRichard Villems
Feb 25, 2010·Current Biology : CB·Pedro SoaresMartin B Richards
Feb 25, 2010·Current Biology : CB·Mark Stoneking, Frederick Delfin
Feb 25, 2010·Current Biology : CB·Manfred Kayser

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Citations

Jan 20, 2016·Nature Communications·Rui MartinianoDaniel G Bradley
Oct 23, 2016·Forensic Science International. Genetics·Allah RakhaYong-Gang Yao
Feb 1, 2017·Annals of Human Biology·Slobodan DavidovicNatasa Kovacevic-Grujicic
Apr 8, 2017·Scientific Reports·Hovhannes SahakyanRichard Villems
Dec 8, 2017·Journal of Human Genetics·Miroslava DerenkoBoris Bazarov
Nov 11, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A RamosM Lima
Apr 25, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Gustavo M TavaresNelson J R Fagundes
Jun 28, 2018·Molecular Genetics and Genomics : MGG·Boris MalyarchukMária Judit Molnár
May 21, 2020·Nature·Jean-Jacques HublinTsenka Tsanova
Aug 21, 2019·PeerJ·António AmorimNuno Taveira
May 28, 2020·Frontiers in Genetics·Ruaidhri CappaAmy J McKnight
Jul 25, 2020·American Journal of Human Genetics·Steven J MichelettiJoanna L Mountain
Feb 16, 2021·International Journal of Legal Medicine·Fu-Chi YangJames Chun-I Lee
Jan 23, 2021·International Journal of Molecular Sciences·Federica FazziniHansi Weissensteiner
Nov 4, 2020·Genes·Cassandra R TaylorCharla Marshall
Apr 29, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C G M SantosR Silva
May 23, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Troy J KieranTravis C Glenn
Sep 30, 2021·The Plant Journal : for Cell and Molecular Biology·Hao LiuMin Xu

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Methods Mentioned

BETA
PCR
deamination

Software Mentioned

ADNA
MITOMAP

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