Maternal and cord blood ghrelin in the pregnancies of smoking mothers: possible markers of nutrient availability for the fetus

Hormone Research
Natacha Bouhours-NouetRégis Coutant

Abstract

To investigate the role of ghrelin in maternal and fetal metabolism, we determined its value in maternal smoking, a specific cause of reduced placenta function and fetal growth. In 85 normal term pregnancies, 42 in smoking and 43 in non-smoking mothers, we measured ghrelin in the maternal blood at the onset of labor and in the cord blood of their 85 singletons immediately after birth. We determined the relationships between ghrelin and placental GH (PGH), pituitary GH (pitGH), and IGF-I. The newborns of smoking mothers weighed 0.24 kg less (p < 0.05) than those of non-smoking mothers. Cord blood ghrelin was 71% higher and PGH and cord blood IGF-I were 34% and 32% lower, respectively, in the pregnancies of smoking compared with non-smoking mothers (p < 0.05). Cord blood ghrelin was unrelated to pitGH and cord blood IGF-I. Maternal ghrelin was unchanged in smoking mothers, increased with maternal fasting duration (r = 0.26, p < 0.05), showed no correlation with PGH and negative correlation with cord blood IGF-I (r = -0.42, p < 0.01). The decrease in placental function and fetal growth in smoking mothers is associated with an increase in cord blood ghrelin, and no change in maternal ghrelin. Maternal ghrelin concentration increase...Continue Reading

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Citations

Jan 9, 2013·Archives of Gynecology and Obstetrics·Ayla Sargın OruçNuri Danışman
Aug 28, 2010·International Journal of Peptides·Johannes D Veldhuis, Cyril Y Bowers
Apr 19, 2008·Clinical Endocrinology·Francisco Méndez-RamírezJuan Manuel Malacara
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·K KosH Randeva

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