Maternal and environmental risk factors for neonatal AKI and its long-term consequences

Nature Reviews. Nephrology
Norberto PericoGiuseppe Remuzzi

Abstract

Acute kidney injury (AKI) is a common and life-threatening complication in critically ill neonates. Gestational risk factors for AKI include premature birth, intrauterine growth restriction and low birthweight, which are associated with poor nephron development and are often the consequence of pre-gestational and gestational factors, such as poor nutritional status. Our understanding of how to best optimize renal development and prevent AKI is in its infancy; however, the identification of pre-gestational and gestational factors that increase the risk of adverse neonatal outcomes and the implementation of interventions, such as improving nutritional status early in pregnancy, have the potential to optimize fetal growth and reduce the risk of preterm birth, thereby improving kidney health. The overall risk of AKI among critically ill and premature neonates is exacerbated postnatally as these infants are often exposed to dehydration, septic shock and potentially nephrotoxic medications. Strategies to improve outcomes - for example, through careful evaluation of nephrotoxic drugs - may reduce the incidence of AKI and its consequences among this population. Management strategies and updated technology that will support neonates wit...Continue Reading

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Dec 12, 2018·Current Opinion in Nephrology and Hypertension·Luca PericoAriela Benigni
May 7, 2020·Current Opinion in Pediatrics·Asaf LebelMichael Zappitelli
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Jun 2, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Huiying WangXiangyu Gao
Aug 15, 2021·Advances in Chronic Kidney Disease·Rupesh RainaHui Kim Yap

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